Chen Jianfei, Tang Congyu, Geng Zhidan, You Qiqin, Cao Hongli, Wang Wenping, Yu Qing, Yuan Haixia
Department of Ultrasound, Zhongshan Hospital of Fudan University, Shanghai, China.
Department of Ultrasound, Zhongshan Hospital (Qingpu), Fudan University, Shanghai, China.
J Clin Ultrasound. 2025 Jan;53(1):207-212. doi: 10.1002/jcu.23830. Epub 2024 Sep 18.
Inflammatory liposarcoma is one of the rarest subtypes of well-differentiated liposarcoma. We present an extremely rare case of well-differentiated inflammatory liposarcoma that occurs in the muscularis of the gallbladder, which was difficult to diagnose before surgery due to the lack of specific clinical and imaging findings. Since cyclin-dependent kinase 4 (CDK4) and murine double minute 2 (MDM2) both displayed amplification in this case, they are not only important markers for auxiliary diagnosis but also the focus of current targeted therapy.
炎症性脂肪肉瘤是高分化脂肪肉瘤中最罕见的亚型之一。我们报告了一例极其罕见的发生于胆囊肌层的高分化炎症性脂肪肉瘤病例，由于缺乏特异性的临床和影像学表现，术前很难诊断。由于该病例中细胞周期蛋白依赖性激酶4（CDK4）和鼠双微体2（MDM2）均显示扩增，它们不仅是辅助诊断的重要标志物，也是当前靶向治疗的重点。
