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确定胆囊脂肪肉瘤原发部位及鉴别诊断时的影像学和组织病理学考量

Imaging and histopathological considerations in determining the primary site and differential diagnosis of gallbladder liposarcoma.

作者信息

Ichikawa Jiro, Furuya Shinji, Kawasaki Tomonori, Onohara Kojiro, Wako Masanori, Ochiai Satoshi, Hagino Tetsuo, Haro Hirotaka

机构信息

Department of Orthopedic Surgery, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan.

First Department of Surgery, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan.

出版信息

World J Surg Oncol. 2025 Jul 1;23(1):256. doi: 10.1186/s12957-025-03915-x.

DOI:10.1186/s12957-025-03915-x
PMID:40598262
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12220646/
Abstract

This study aimed to address the article by Yang et al., titled “.” The authors reported an extremely rare case of a large atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL) arising in the gallbladder, diagnosed through imaging and histopathological findings. However, due to the tumor’s exceptional size, the positional relationship between the gallbladder and the tumor remains unclear. In such cases, it is essential to histologically analyze the interface between the tumor and the gallbladder. Additionally, imaging revealed both fatty and non-fatty components, necessitating consideration of dedifferentiated liposarcoma as a differential diagnosis. In light of these factors, this study discusses the specific information required for further evaluation and accurate diagnosis.

摘要

本研究旨在探讨Yang等人发表的题为“.”的文章。作者报告了一例极为罕见的发生于胆囊的巨大非典型脂肪瘤性肿瘤/高分化脂肪肉瘤(ALT/WDL),通过影像学和组织病理学检查确诊。然而,由于肿瘤尺寸异常,胆囊与肿瘤之间的位置关系仍不明确。在此类病例中,对肿瘤与胆囊之间的界面进行组织学分析至关重要。此外,影像学显示肿瘤既有脂肪成分又有非脂肪成分,因此需要将去分化脂肪肉瘤作为鉴别诊断考虑在内。鉴于这些因素,本研究讨论了进一步评估和准确诊断所需的具体信息。

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本文引用的文献

1
Primary giant liposarcoma of the gallbladder: a case report and literature review.胆囊原发性巨大脂肪肉瘤:一例报告及文献复习
World J Surg Oncol. 2025 Feb 22;23(1):61. doi: 10.1186/s12957-025-03711-7.
2
Primary dedifferentiated liposarcoma of the gallbladder: a case report and literature review.胆囊原发性去分化脂肪肉瘤:一例报告并文献复习
Front Surg. 2024 Nov 13;11:1452144. doi: 10.3389/fsurg.2024.1452144. eCollection 2024.
3
Case report: a rare clinical presentation of a difficult diagnosis of dedifferentiated liposarcoma showing leiomyosarcoma phenotype in the ileocecal region.病例报告:回盲部出现显示平滑肌肉瘤表型的去分化脂肪肉瘤,诊断困难,临床表现罕见。
Front Oncol. 2024 Nov 11;14:1425809. doi: 10.3389/fonc.2024.1425809. eCollection 2024.
4
The novel role of MDM2 in the diagnosis and treatment of dedifferentiated liposarcoma.MDM2在去分化脂肪肉瘤诊断与治疗中的新作用。
Front Oncol. 2024 Oct 18;14:1466399. doi: 10.3389/fonc.2024.1466399. eCollection 2024.
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Well-differentiated inflammatory liposarcoma in the muscularis of the gallbladder.胆囊肌层中高分化炎性脂肪肉瘤。
J Clin Ultrasound. 2025 Jan;53(1):207-212. doi: 10.1002/jcu.23830. Epub 2024 Sep 18.
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Nature of histopathology in atypical lipomatous tumor/well-differentiated liposarcoma diagnosis.非典型脂肪瘤性肿瘤/高分化脂肪肉瘤诊断中组织病理学的性质
J Dig Dis. 2024 May;25(5):328-330. doi: 10.1111/1751-2980.13293. Epub 2024 Jun 21.
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Retroperitoneal Soft Tissue Sarcoma: Emerging Therapeutic Strategies.腹膜后软组织肉瘤:新兴治疗策略
Cancers (Basel). 2023 Nov 18;15(22):5469. doi: 10.3390/cancers15225469.
8
Dedifferentiated liposarcoma with abrupt transition of low-grade and high-grade dedifferentiation: A rare case report.去分化脂肪肉瘤中低级和高级去分化的急剧转变:一例罕见病例报告。
Int J Immunopathol Pharmacol. 2021 Jan-Dec;35:20587384211048565. doi: 10.1177/20587384211048565.
9
Liposarcoma of gallbladder: a case report and literature review.胆囊脂肪肉瘤:一例报告及文献综述
J Surg Case Rep. 2021 Jun 22;2021(6):rjab273. doi: 10.1093/jscr/rjab273. eCollection 2021 Jun.
10
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