Imaging and histopathological considerations in determining the primary site and differential diagnosis of gallbladder liposarcoma.

This study aimed to address the article by Yang et al., titled “.” The authors reported an extremely rare case of a large atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL) arising in the gallbladder, diagnosed through imaging and histopathological findings. However, due to the tumor’s exceptional size, the positional relationship between the gallbladder and the tumor remains unclear. In such cases, it is essential to histologically analyze the interface between the tumor and the gallbladder. Additionally, imaging revealed both fatty and non-fatty components, necessitating consideration of dedifferentiated liposarcoma as a differential diagnosis. In light of these factors, this study discusses the specific information required for further evaluation and accurate diagnosis.