淋巴细胞性慢性粒细胞白血病急变期54条染色体超二倍体伴双Ph1染色体
Hyperdiploidy of 54 chromosomes with double Ph1 chromosome in lymphoid chronic myelocytic leukemic blast crisis.
作者信息
Clemm C, Thiel E, Riess H, Loy A, Wilmanns W
出版信息
Acta Haematol. 1985;73(3):163-7. doi: 10.1159/000206311.
Cytogenetic analysis of bone marrow cells in a 40-year-old man revealed a mosaic of two cell lines during blast crisis: one diploid with typical Ph1 chromosome (46 XY Ph1) and one with hyperdiploidy of 54 chromosomes with double Ph1 chromosome, trisomy 4, 6, 8, 18, 21 and duplication of the sex chromosomes X and Y. Immunological characterization showed common acute lymphoblastic leukemia antigen in 90% of the blasts. In spite of intensive chemotherapy the patient died in a third blast crisis 15 months after the first blast crisis, 3 months after successfully treated central nervous system relapse.
对一名40岁男性的骨髓细胞进行细胞遗传学分析发现，在原始细胞危象期间存在两种细胞系的嵌合体：一种为具有典型Ph1染色体的二倍体（46 XY Ph1），另一种为具有54条染色体超二倍体且有双Ph1染色体、4号、6号、8号、18号、21号染色体三体以及性染色体X和Y重复。免疫特征显示90%的原始细胞中有常见的急性淋巴细胞白血病抗原。尽管进行了强化化疗，但患者在首次原始细胞危象15个月后、中枢神经系统复发成功治疗3个月后死于第三次原始细胞危象。
Zotero 插件