Different cell clones in bone marrow and spleen of a patient with chronic myelocytic leukemia (CML) in blastic phase.
作者信息
Olinici C D, Petrov L, Macavei I, Dobay O
出版信息
Cancer. 1978 Dec;42(6):2707-9. doi: 10.1002/1097-0142(197812)42:6<2707::aid-cncr2820420627>3.0.co;2-5.
Abstract
The chromosome study of a patient with chronic myelocytic leukemia in blastic phase revealed a 46,XY,Ph1/47,XY,Ph1,+8 cytogenetic constitution in bone marrow cells and a 46,XY,Ph1/48,XY,2Ph1,+19 cytogenetic constitution in spleen cells. As the cell clones exhibiting chromosome abnormalities in addition to the Ph1 chromosome evolved apparently independently, it is suggested that the acute transformation had a bifocal, myeloid and splenic origin.
摘要
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