一例急性未分化白血病中的显著亚二倍体。

Marked hypodiploidy in a case of acute undifferentiated leukemia.

作者信息

Como R, Sarna G, Sparkes R S

出版信息

Am J Hematol. 1979;6(2):143-7. doi: 10.1002/ajh.2830060206.

Abstract

A-29-year-old white man with acute undifferentiated leukemia had bone marrow cells with predominantly 42 chromosomes including several rearrangements. Following a brief induced "complete" remission, during which normal chromosomes were observed, bone marrow cells with 42 chromosomes but a different karyotype than before remission were found. Evaluation of that karyotype indicates not only a reduced chromosome count but also a reduced quantity of chromosome material.

摘要

一名29岁的白人男性患有急性未分化白血病，其骨髓细胞主要有42条染色体，包括几种重排。在短暂诱导“完全”缓解期间观察到正常染色体，之后发现骨髓细胞有42条染色体，但核型与缓解前不同。对该核型的评估表明，不仅染色体数目减少，而且染色体物质的数量也减少。