一种用于在活体动植物组织中高效检测氟离子的新型荧光探针。
A novel fluorescent probe for efficient detection of fluoride ions in living animal and plant tissues.
机构信息
College of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqing 401331, PR China.
Chongqing Key Laboratory of High Active Traditional Chinese Drug Delivery System, Chongqing Engineering Research Center of Pharmaceutical Sciences, Chongqing Medical and Pharmaceutical College, Chongqing 404120, PR China.
出版信息
Anal Methods. 2024 Oct 31;16(42):7139-7147. doi: 10.1039/d4ay01407c.
This work presents the design and synthesis of a new fluorescent probe IF-Br-F for the specific detection of fluoride ions. The IF-Br-F probe has excellent fluorescence properties, and the mechanism of the probe response to fluoride ions was successfully verified HRMS and DFT calculations. IF-Br-F has high sensitivity and low detection limit (5.82 × 10 mol L) and successfully detects fluoride ions in actual water samples. The probe can be applied to fluorescence imaging of zebrafish, cells, and roots and exhibits low cytotoxicity and good biocompatibility.
本工作设计并合成了一种新型荧光探针 IF-Br-F，用于对氟离子的特异性检测。IF-Br-F 探针具有优异的荧光性质，其对氟离子的探针响应机制通过高分辨率质谱（HRMS）和密度泛函理论（DFT）计算得到了成功验证。IF-Br-F 具有高灵敏度和低检测限（5.82×10 mol L），并成功检测了实际水样中的氟离子。该探针可用于斑马鱼、细胞和根的荧光成像，表现出低细胞毒性和良好的生物相容性。
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