血清血管内皮生长因子在溃疡性结肠炎的诊断和预后中有意义。
Serum vascular endothelial growth factor has diagnostic and prognostic significance in ulcerative colitis.
机构信息
Department of Internal Medicine, Sultan 2. Abdülhamid Han Training and Research Hospital, Health Sciences University, İstanbul, Turkiye.
Department of Gastroenterology, Kartal Dr. Lütfi Kırdar Training and Research Hospital, Health Sciences University, İstanbul, Turkiye.
出版信息
Turk J Med Sci. 2024 May 17;54(4):718-726. doi: 10.55730/1300-0144.5841. eCollection 2024.
BACKGROUND/AIM: In ulcerative colitis (UC), serum vascular endothelial growth factor (sVEGF) concentrations are elevated and there are conflicting results about serum calprotectin (SCP) and sVEGF as biomarkers. We aimed to evaluate the relationship between sVEGF and SCP levels in UC patients and the associations of these molecules with the phenotypes of UC.
MATERIALS AND METHODS
This prospective case-control study included 60 UC patients and 30 healthy controls. The Mayo Clinical Score (MCS) was used to evaluate patients' clinical features and the Mayo Endoscopic Score (MES) was used to evaluate endoscopic features of the cases. The method proposed by Truelove and Richards was applied in calculating the histology activity index (HAI). Human sVEGF (Cat.E0080Hu) and human calprotectin (Cat.E4010Hu) kits were used for the enzyme-linked immunosorbent assay (ELISA) measurements of sVEGF and SCP levels.
RESULTS
The median sVEGF and SCP levels were higher in the patient group compared to the healthy control group [2139 ng/L (126-5783) vs. 888 ng/L (715-5270), p = 0.002 and 932 ng/L (99-2648) vs. 80 ng/L (56-920), p < 0.001, respectively]. There was a strong correlation between SCP and sVEGF values (rho = 0.819, p < 0.001). The MCS, MES, and HAI values were positively correlated with sVEGF and SCP concentrations.
CONCLUSION
sVEGF and SCP may be valuable auxiliary biomarkers for UC.
背景/目的：在溃疡性结肠炎（UC）中，血清血管内皮生长因子（sVEGF）浓度升高，而血清钙卫蛋白（SCP）和 sVEGF 作为生物标志物的结果存在争议。我们旨在评估 UC 患者 sVEGF 和 SCP 水平之间的关系，以及这些分子与 UC 表型的关联。
材料和方法
本前瞻性病例对照研究纳入了 60 例 UC 患者和 30 名健康对照者。采用 Mayo 临床评分（MCS）评估患者的临床特征，采用 Mayo 内镜评分（MES）评估病例的内镜特征。采用 Truelove 和 Richards 提出的方法计算组织学活动指数（HAI）。采用酶联免疫吸附试验（ELISA）法检测 sVEGF 和 SCP 水平，试剂盒为人 sVEGF（Cat.E0080Hu）和人 calprotectin（Cat.E4010Hu）。
结果
与健康对照组相比，患者组 sVEGF 和 SCP 中位数水平较高[2139ng/L（126-5783）比 888ng/L（715-5270），p=0.002 和 932ng/L（99-2648）比 80ng/L（56-920），p<0.001]。SCP 和 sVEGF 值之间存在很强的相关性（rho=0.819，p<0.001）。MCS、MES 和 HAI 值与 sVEGF 和 SCP 浓度呈正相关。
结论
sVEGF 和 SCP 可能是 UC 的有价值的辅助生物标志物。
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