Shi Jin-Tong, Chen Nuo, Xu Jia, Goyal Hemant, Wu Zhi-Qi, Zhang Jie-Xin, Xu Hua-Guo
Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Division of Gastroenterology, Hepatology & Nutrition, University of Texas Health Sciences Center, Houston, TX 77030, USA.
J Clin Med. 2023 Feb 2;12(3):1206. doi: 10.3390/jcm12031206.
Fecal calprotectin (FC) levels correlate with the disease activity of inflammatory bowel diseases (IBD); however, the utility of FC in predicting IBD relapse remains to be determined. We aim to evaluate the efficacy of fecal calprotectin in predicting the relapse of inflammatory bowel disease. We searched Pubmed (MEDLINE), Embase, Web of Science, and the Cochrane library databases up to 7 July 2021. Our study estimated the pooled sensitivity and specificity, summary receiver operating characteristic (SROC) curve, and the optimal cut-off value for predicting IBD relapse using a multiple threshold model. A total of 24 prospective studies were included in the meta-analysis. The optimal FC cut-off value was 152 μg/g. The pooled sensitivity and specificity of FC was 0.720 (0.528 to 0.856) and 0.740 (0.618 to 0.834), respectively. FC is a useful, non-invasive, and inexpensive biomarker for the early prediction of IBD relapse. An FC value of 152 μg/g is an ideal threshold to identify patients with a high relapse probability.
粪便钙卫蛋白（FC）水平与炎症性肠病（IBD）的疾病活动相关；然而，FC在预测IBD复发中的效用仍有待确定。我们旨在评估粪便钙卫蛋白在预测炎症性肠病复发方面的疗效。我们检索了截至2021年7月7日的Pubmed（MEDLINE）、Embase、Web of Science和Cochrane图书馆数据库。我们的研究使用多阈值模型估计了合并敏感性和特异性、汇总接受者操作特征（SROC）曲线以及预测IBD复发的最佳临界值。荟萃分析共纳入24项前瞻性研究。FC的最佳临界值为152μg/g。FC的合并敏感性和特异性分别为0.720（0.528至0.856）和0.740（0.618至0.834）。FC是一种用于早期预测IBD复发的有用、非侵入性且廉价的生物标志物。152μg/g的FC值是识别高复发概率患者的理想阈值。
