Fukui I, Sekine H, Yamada T, Kihara K
Hinyokika Kiyo. 1985 Apr;31(4):623-6.
Intravesical chemotherapy with sequential instillation of mitomycin C and adriamycin was carried out on 19 patients with superficial bladder cancer (Ta, T1 and Tis). Twenty milligram of mitomycin C on day 1 and 40 mg of adriamycin on day 2 were instilled into the bladder, this treatment being repeated weekly for 5 consecutive weeks if there were no serious side effects. The following results were obtained. Of 16 evaluable patients, 10 patients (63%) achieved complete response and 2 patients achieved partial response, 4 patients showing no response. In patients with high grade tumor, especially with carcinoma in situ, a high CR rate (6/7 or 86%) was achieved. Chemical cystitis occurred in 10 out of 19 (53%) patients. In 5 of the 6 patients who suffered from severe cystitis symptoms, treatment was discontinued. However, the symptoms resolved within 4 weeks in all patients.
对19例浅表性膀胱癌（Ta、T1和Tis）患者进行了丝裂霉素C和阿霉素序贯膀胱内化疗。第1天向膀胱内灌注20毫克丝裂霉素C，第2天灌注40毫克阿霉素，若没有严重副作用，则连续5周每周重复此治疗。获得了以下结果。在16例可评估的患者中，10例患者（63%）达到完全缓解，2例患者达到部分缓解，4例患者无反应。在高级别肿瘤患者中，尤其是原位癌患者，完全缓解率较高（6/7或86%）。19例患者中有10例（53%）发生化学性膀胱炎。6例出现严重膀胱炎症状的患者中有5例停止了治疗。然而，所有患者的症状均在4周内缓解。
