Zhao Ziwen, Wang Chenxu, Liu Aiguo, Bai Ning, Jiang Bo, Mao Yuanfu, Ying Ting, Dong Daming, Yi Chengqing, Li Dejian
Department of Orthopedics, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Department of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, China.
Front Bioeng Biotechnol. 2024 Sep 4;12:1448010. doi: 10.3389/fbioe.2024.1448010. eCollection 2024.
Pharmacologic treatment of orthopedic diseases is a common challenge for clinical orthopedic surgeons, and as an important step in the stepwise treatment of orthopedic diseases, it is often difficult to achieve satisfactory results with existing pharmacologic treatments. Therefore, it is increasingly important to find new ways to effectively improve the treatment pattern of orthopedic diseases as well as to enhance the therapeutic efficacy. It has been found that metal-organic frameworks (MOFs) possess the advantages of high specific surface area, high porosity, chemical stability, tunability of structure and biocompatibility. Therefore, MOFs are expected to improve the conventional traditional treatment modality for bone diseases. This manuscript reviewed the applications of MOFs in the treatment of common clinical bone diseases and look forward to its future development.
骨科疾病的药物治疗是临床骨科医生面临的一项常见挑战，作为骨科疾病阶梯治疗中的重要一环，现有的药物治疗往往难以取得令人满意的效果。因此，寻找有效改善骨科疾病治疗模式并提高治疗效果的新方法变得越来越重要。研究发现，金属有机框架（MOFs）具有高比表面积、高孔隙率、化学稳定性、结构可调节性和生物相容性等优点。因此，MOFs有望改善传统的骨疾病治疗方式。本文综述了MOFs在常见临床骨疾病治疗中的应用，并展望了其未来发展。
