Zhao Chaoqian, Shu Chaoqin, Yu Jiangming, Zhu Yufang
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, PR China.
Department of Orthopaedics, Tongren Hospital, Shanghai Jiaotong University, Shanghai, 200336, PR China.
Mater Today Bio. 2023 Jun 27;21:100717. doi: 10.1016/j.mtbio.2023.100717. eCollection 2023 Aug.
Bone defects induced by bone trauma, tumors and osteoarthritis greatly affect the life quality and health of patients. The biomaterials with numerous advantages are becoming the most preferred options for repairing bone defects and treating orthopedic diseases. However, their repairing effects remains unsatisfactory, especially in bone defects suffering from tumor, inflammation, and/or bacterial infection. There are several strategies to functionalize biomaterials, but a more general and efficient method is essential for accomplishing the functionalization of biomaterials. Possessing high specific surface, high porosity, controlled degradability and variable composition, metal-organic frameworks (MOFs) materials are inherently advantageous for functionalizing biomaterials, with tremendous improvements having been achieved. This review summarizes recent progresses in MOFs functionalized biomaterials for promoting bone repair and therapeutic effects. In specific, by utilizing various properties of diverse MOFs materials, integrated MOFs functionalized biomaterials achieve enhanced bone regeneration, antibacterial, anti-inflammatory and anti-tumor functions. Finally, the summary and prospects of on the development of MOFs-functionalized biomaterials for promoting bone repair were discussed.
由骨创伤、肿瘤和骨关节炎引起的骨缺损极大地影响患者的生活质量和健康。具有众多优势的生物材料正成为修复骨缺损和治疗骨科疾病的最优选方案。然而，它们的修复效果仍不尽人意，尤其是在患有肿瘤、炎症和/或细菌感染的骨缺损中。有几种使生物材料功能化的策略，但一种更通用、更有效的方法对于实现生物材料的功能化至关重要。金属有机框架（MOFs）材料具有高比表面积、高孔隙率、可控降解性和可变组成，在使生物材料功能化方面具有固有优势，并且已经取得了巨大进展。本文综述了MOFs功能化生物材料在促进骨修复和治疗效果方面的最新进展。具体而言，通过利用不同MOFs材料的各种特性，集成的MOFs功能化生物材料实现了增强的骨再生、抗菌、抗炎和抗肿瘤功能。最后，讨论了MOFs功能化生物材料促进骨修复发展的总结与展望。
