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供体肝切除时间与肝移植结局:一个不容忽视的契机。

Donor hepatectomy time and liver transplantation outcomes: An opportunity that cannot be dismissed.

作者信息

Gonzalez Cohens Francisca, Gonzalez Fernando M

机构信息

Web Intelligence Centre, Faculty of Physics and Mathematical Sciences, Universidad de Chile, Santiago 7500922, Chile.

Department of Nephrology, Faculty of Medicine, Universidad de Chile, Santiago 7500922, Chile.

出版信息

World J Transplant. 2024 Sep 18;14(3):92859. doi: 10.5500/wjt.v14.i3.92859.

Abstract

The probability of developing primary dysfunction (PD) is a function of the probability of ischemia/reperfusion (I/R) injury. The probability of I/R injury in turn, is a function of several donor and transplantation process variables, among which is ischemia time. Custodio studied the duration of a special type of warm ischemia and showed, contrary to what is known, that a longer duration is not statistically different from a shorter one in PD development. This finding opens the door to the unforeseen opportunity of training fellows in performing hepatectomies, since the duration will not jeopardize liver transplant outcomes, albeit with some precautions.

摘要

发生原发性功能障碍(PD)的概率是缺血/再灌注(I/R)损伤概率的函数。而I/R损伤的概率又是几个供体和移植过程变量的函数,其中包括缺血时间。Custodio研究了一种特殊类型的热缺血持续时间,并表明,与已知情况相反,在PD发生方面,较长的持续时间与较短的持续时间在统计学上并无差异。这一发现为培训学员进行肝切除术带来了意想不到的机会,因为尽管需要一些预防措施,但该持续时间不会危及肝移植结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9f9/11317848/03e4d3441369/92859-g001.jpg

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