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无需散瞳的活体人类视网膜长时间自适应光学扫描激光眼科显微镜成像：一项可行性研究。

Extended-period AOSLO imaging in the living human retina without pupil dilation: a feasibility study.

作者信息

Cui Jiahe, Villamil Maria, Schneider Allie C, Lawton Penelope F, Young Laura K, Booth Martin J, Smithson Hannah E

机构信息

Department of Engineering Science, University of Oxford, Parks Road, Oxford OX1 3PJ, United Kingdom.

Department of Experimental Psychology, University of Oxford, Anna Watts Building, Radcliffe Observatory Quarter, Woodstock Road, Oxford OX2 6GG, United Kingdom.

出版信息

Biomed Opt Express. 2024 Aug 2;15(9):4995-5008. doi: 10.1364/BOE.531808. eCollection 2024 Sep 1.

DOI:10.1364/BOE.531808
PMID:39296415
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11407263/
Abstract

imaging using an adaptive optics scanning laser ophthalmoscope (AOSLO) is challenging, especially over extended periods. Pharmacological agents, administered as eye drops, are commonly used to dilate the pupil and paralyse accommodation, to improve image quality. However, they are contraindicated in some scenarios. Here, we evaluate the feasibility and reproducibility of performing AOSLO imaging without pharmacological pupil dilation over 1.5 hours with visual stimulation. Through statistical analysis and theoretical modelling using a dataset of retinal and pupil images collected from six healthy, young, near-emmetropic participants between the ages of 20-30 years, we validate that the retinal image quality does not change significantly with time in the experimental session ( = 0.33), and that pupil size has a strong effect on image quality but is not the only contributing factor.

摘要

使用自适应光学扫描激光检眼镜（AOSLO）进行成像具有挑战性，尤其是在长时间成像时。通常使用眼药水形式的药物制剂来散瞳和麻痹调节功能，以提高图像质量。然而，在某些情况下它们是禁忌的。在此，我们评估了在视觉刺激下不使用药物散瞳进行1.5小时AOSLO成像的可行性和可重复性。通过对从6名年龄在20至30岁之间的健康、年轻、近正视参与者收集的视网膜和瞳孔图像数据集进行统计分析和理论建模，我们验证了在实验过程中视网膜图像质量不会随时间显著变化（=0.33），并且瞳孔大小对图像质量有很大影响，但不是唯一的影响因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5b9/11407263/00119b01e643/boe-15-9-4995-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5b9/11407263/96931fdcb579/boe-15-9-4995-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5b9/11407263/a3aedea5f176/boe-15-9-4995-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5b9/11407263/fe3c2a30231a/boe-15-9-4995-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5b9/11407263/55f786030b0c/boe-15-9-4995-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5b9/11407263/00119b01e643/boe-15-9-4995-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5b9/11407263/96931fdcb579/boe-15-9-4995-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5b9/11407263/a3aedea5f176/boe-15-9-4995-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5b9/11407263/fe3c2a30231a/boe-15-9-4995-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5b9/11407263/55f786030b0c/boe-15-9-4995-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5b9/11407263/00119b01e643/boe-15-9-4995-g005.jpg

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