布比卡因腋路阻滞后对二氧化碳的通气反应。

Ventilatory response to CO2 following axillary blockade with bupivacaine.

作者信息

Negre I, Labaille T, Samii K, Noviant Y

出版信息

Anesthesiology. 1985 Oct;63(4):401-3. doi: 10.1097/00000542-198510000-00010.

DOI:10.1097/00000542-198510000-00010

Abstract

The systemic effect of bupivacaine on the control of ventilation was studied in eight ASA I (six male, two female) unpremedicated healthy subjects aged 30-55 yr (mean 43.5 yr) and weighing 59-82 kg (mean 69 kg) after axillary blockade with bupivacaine 0.5% without epinephrine, 3 mg/kg. The slope of the ventilatory response to CO2 was significantly increased (P less than 0.05) from its control value (1.77 +/- 1.03 l X min-1 X mmHg-1 [mean +/- SD]) 30 min (+19 +/- 32%) and 60 min (+32 +/- 37%) after axillary blockade, while plasma bupivacaine levels were 1.65 +/- 0.82 and 1.40 +/- 0.60 micrograms/ml, respectively. The correlation between individual plasma bupivacaine levels and the changes in the slope of the ventilatory response to CO2 was significant (r = 0.57, n = 16, P less than 0.05). Resting minute ventilation and end-tidal CO2 values did not change significantly. These results suggest that bupivacaine has a systemic stimulating effect on the ventilatory control mechanisms.

摘要

在8名年龄为30 - 55岁（平均43.5岁）、体重59 - 82千克（平均69千克）的ASA I级（6名男性，2名女性）未使用术前药的健康受试者中，研究了布比卡因在无肾上腺素的0.5%布比卡因3毫克/千克腋路阻滞术后对通气控制的全身效应。腋路阻滞后30分钟（增加19±32%）和60分钟（增加32±37%）时，对二氧化碳通气反应的斜率较其对照值（1.77±1.03升·分钟⁻¹·毫米汞柱⁻¹[平均值±标准差]）显著增加（P<0.05），而血浆布比卡因水平分别为1.65±0.82和1.40±0.60微克/毫升。个体血浆布比卡因水平与对二氧化碳通气反应斜率变化之间的相关性显著（r = 0.57，n = 16，P<0.05）。静息分钟通气量和呼气末二氧化碳值无显著变化。这些结果表明，布比卡因对通气控制机制有全身刺激作用。