Chandler Antoinette, Wood Hannah, Nezamololama Novin, Gooderham Melinda J
Trent University, Peterborough, ON, Canada.
SKiN Centre for Dermatology, Peterborough, ON, Canada.
J Psoriasis Psoriatic Arthritis. 2022 Jul;7(3):117-121. doi: 10.1177/24755303221099292. Epub 2022 May 6.
Palmoplantar pustulosis (PPP) is a chronic skin condition characterized by sterile pustules on the palms and soles. This condition is more commonly reported among women and smokers causing considerable discomfort and interference with daily activities. Although there are various off-label treatment options available for PPP, there remains a demand to identify more effective and safer treatments.
To review the patient demographics and treatment patterns of our PPP patient population.
A retrospective chart review was performed at a dermatology office with two locations in Ontario, Canada.
We identified 71 adult PPP patients. A third of patients did not return for follow up after diagnosis. Among those who returned for follow-up, 20% were managed with topical therapy alone. Of our patients who took systemic treatment for PPP, apremilast, followed by ustekinumab and guselkumab, had the greatest retention of therapy.
Targeting PDE4, IL-12/23 and IL-23 provided some benefit for our patients with PPP leading to greatest retention of therapy over time. Further investigation is required into the cause for high no-show rates and the search for effective and safe treatment options.
掌跖脓疱病（PPP）是一种慢性皮肤病，其特征为手掌和脚底出现无菌性脓疱。这种疾病在女性和吸烟者中更为常见，会导致相当大的不适并干扰日常活动。尽管有多种非标签治疗方案可用于PPP，但仍需要确定更有效、更安全的治疗方法。
回顾我们的PPP患者群体的人口统计学特征和治疗模式。
在加拿大安大略省有两个地点的皮肤科诊所进行了一项回顾性病历审查。
我们确定了71例成年PPP患者。三分之一的患者在诊断后未返回进行随访。在返回进行随访的患者中，20%仅接受局部治疗。在我们接受PPP全身治疗的患者中，阿普米拉斯（apremilast），其次是乌司奴单抗（ustekinumab）和古塞库单抗（guselkumab），治疗持续率最高。
靶向磷酸二酯酶4（PDE4）、白细胞介素12/23（IL-12/23）和白细胞介素23（IL-23）对我们的PPP患者有一定益处，随着时间推移导致治疗持续率最高。需要进一步调查高未就诊率的原因，并寻找有效和安全的治疗选择。
