Sakuraba H, Iimori Y, Suzuki Y, Kint J A, Akagi M
Ann Neurol. 1985 Aug;18(2):261-3. doi: 10.1002/ana.410180215.
Serum beta-galactosidase activity was found to be markedly increased in clotting blood from normal subjects, but patients with galactosialidosis showed only a slight increase of this enzyme activity. Consequently, the beta-galactosidase activity was low in serum after long-term clotting in patients with this disease. The mechanism of the enzyme activation is unknown. The use of anticoagulants completely inhibited the activation.
在正常受试者的凝血血液中，血清β-半乳糖苷酶活性显著升高，但患有半乳糖唾液酸贮积症的患者该酶活性仅略有增加。因此，患有这种疾病的患者在长期凝血后血清中的β-半乳糖苷酶活性较低。酶激活的机制尚不清楚。使用抗凝剂可完全抑制激活。
