新型抗假单胞菌头孢菌素头孢咪唑（U-63196E）的体外比较评价

Comparative in vitro evaluation of cefpimizole (U-63196E), a new antipseudomonal cephalosporin.

作者信息

LeFrock J L, Smith B R, Bihl J

出版信息

Antimicrob Agents Chemother. 1985 Jul;28(1):133-7. doi: 10.1128/AAC.28.1.133.

DOI:10.1128/AAC.28.1.133

PMID:3929676

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC176324/

Abstract

The activity of cefpimizole (formerly U-63196E) was compared with that of other broad-spectrum cephalosporins and penicillins. Overall, cefpimizole exhibited limited activity against gram-positive cocci and members of the family Enterobacteriaceae as compared with the other cephalosporins tested. The activity of cefpimizole against Pseudomonas aeruginosa was similar to that of cefoperazone and mezlocillin (90% MIC, 32 micrograms/ml) but poorer than that of ceftazidime (90% MIC, 8 micrograms/ml). Cefpimizole appears to have no in vitro advantage over the cephalosporins with which it was compared.

摘要

将头孢咪唑（原名U - 63196E）的活性与其他广谱头孢菌素和青霉素进行了比较。总体而言，与所测试的其他头孢菌素相比，头孢咪唑对革兰氏阳性球菌和肠杆菌科成员的活性有限。头孢咪唑对铜绿假单胞菌的活性与头孢哌酮和美洛西林相似（90% MIC为32微克/毫升），但比头孢他啶差（90% MIC为8微克/毫升）。与所比较的头孢菌素相比，头孢咪唑在体外似乎没有优势。