Neu H C, Labthavikul P
Antimicrob Agents Chemother. 1983 Sep;24(3):375-82. doi: 10.1128/AAC.24.3.375.
The in vitro activity of U-63196E, a new broad-spectrum cephalosporin antibiotic, was studied against various gram-positive and gram-negative bacteria and compared with the in vitro activities of cefotaxime, moxalactam, cefoperazone, ceftazidime, and aztreonam. Although U-63196E inhibited many ampicillin-resistant bacteria and its activity against gram-negative species was similar to cefoperazone, it was much less active than the other agents. U-63196E was less active than cefazolin against gram-positive species, and it was less active than cefoxitin or moxalactam against Bacteroides fragilis. U-63196E did not inhibit most cefoperazone- or cefsulodin-resistant Pseudomonas aeruginosa. There was a difference between minimal inhibitory concentrations and minimal bactericidal concentrations for isolates which contained beta-lactamases. Plasmid beta-lactamases of the TEM, HSV, OXA, and PSE types hydrolyzed U-63196E. But U-63196E was relatively stable against hydrolysis by the chromosomal beta-lactamases.
研究了新型广谱头孢菌素抗生素U-63196E对各种革兰氏阳性菌和革兰氏阴性菌的体外活性，并与头孢噻肟、莫西沙星、头孢哌酮、头孢他啶和氨曲南的体外活性进行了比较。虽然U-63196E抑制了许多耐氨苄西林的细菌，且其对革兰氏阴性菌的活性与头孢哌酮相似，但它的活性比其他药物低得多。U-63196E对革兰氏阳性菌的活性低于头孢唑林，对脆弱拟杆菌的活性低于头孢西丁或莫西沙星。U-63196E不能抑制大多数耐头孢哌酮或头孢磺啶的铜绿假单胞菌。对于含有β-内酰胺酶的分离株，最小抑菌浓度和最小杀菌浓度之间存在差异。TEM、HSV、OXA和PSE型质粒β-内酰胺酶可水解U-63196E。但U-63196E对染色体β-内酰胺酶的水解相对稳定。
