Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China.
The Center of Gerontology and Geriatrics, National Clinical Research Center of Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Front Public Health. 2024 Sep 4;12:1416796. doi: 10.3389/fpubh.2024.1416796. eCollection 2024.
To evaluate the association between musculoskeletal pain and incident sarcopenia and further explore the mediating effect of depressive symptoms among middle-aged and older Chinese adults.
Using the data from the China Health and Retirement Longitudinal Study 2011 and 2015, we included 12,788 participants in the cross-sectional analysis and 8,322 for the longitudinal analysis. Musculoskeletal pains located in the neck, back, waist, shoulder, arm, wrist, leg, knee, and ankle were self-reported at baseline and follow-up. The diagnosis criteria of sarcopenia was based on the Asian Working Group for Sarcopenia 2019. Multivariable logistic regression models were used to evaluate the association between musculoskeletal pain, and the Karlson-Holm-Breen (KHB) method was used to explore the mediating effect of depressive symptoms.
Over the 4-year follow-up, 445 participants were identified with incident sarcopenia. In the longitudinal analysis, participants with baseline musculoskeletal pain (adjusted odds ratio (OR): 1.37, 95% confidence interval (CI): 1.07-1.76), persistent musculoskeletal pain (OR:1.68, 95%CI: 1.28-2.24), and persistent waist pain (OR:1.46, 95%CI: 1.04-2.03) were significantly associated with increased the risk of incident sarcopenia. Furthermore, depressive symptoms were found to partially mediate the association between musculoskeletal pain and incident sarcopenia.
Persistent musculoskeletal pain, especially in waist area, was positively associated with a higher risk of sarcopenia among the middle-aged and older Chinese. Depressive symptoms played a partial mediating role in this association.
评估肌肉骨骼疼痛与肌少症发病的相关性，并进一步探讨中年及以上中国成年人抑郁症状的中介作用。
利用中国健康与养老追踪调查 2011 年和 2015 年的数据，我们纳入了横断面分析的 12788 名参与者和纵向分析的 8322 名参与者。基线和随访时自我报告颈部、背部、腰部、肩部、手臂、手腕、腿部、膝盖和脚踝的肌肉骨骼疼痛。肌少症的诊断标准基于 2019 年亚洲肌肉减少症工作组。多变量逻辑回归模型用于评估肌肉骨骼疼痛与肌少症之间的关系，Karlson-Holm-Breen（KHB）方法用于探索抑郁症状的中介作用。
在 4 年的随访中，有 445 名参与者被诊断为肌少症。在纵向分析中，基线时有肌肉骨骼疼痛（调整后的优势比（OR）：1.37，95%置信区间（CI）：1.07-1.76）、持续性肌肉骨骼疼痛（OR：1.68，95%CI：1.28-2.24）和持续性腰痛（OR：1.46，95%CI：1.04-2.03）的参与者发生肌少症的风险显著增加。此外，抑郁症状被发现部分中介了肌肉骨骼疼痛与肌少症发病之间的关系。
持续性肌肉骨骼疼痛，尤其是腰部疼痛，与中国中年及以上人群肌少症的发病风险呈正相关。抑郁症状在这一关联中起着部分中介作用。
