Casulli Maria Antonietta, Yan Ruyu, Takeuchi Satomi, Cesari Andrea, Mancin Fabrizio, Hayashita Takashi, Hashimoto Takeshi, Taurino Irene
Micro and Nano-Systems (MNS), Department of Electrical Engineering (ESAT), Katholieke Universiteit Leuven (KU Leuven), 3001 Leuven, Belgium.
Graduate School of Science and Technology, Department of Materals and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioi-cho, Chiyoda-ku, Tokyo 102-8554, Japan.
ACS Appl Nano Mater. 2024 Aug 27;7(17):20153-20162. doi: 10.1021/acsanm.4c02972. eCollection 2024 Sep 13.
Curcumin (CUR), a polyphenolic substance from turmeric, displays diverse medicinal properties. However, its instability poses challenges in detection. Cyclodextrin-based nanogels (CyDngs) offer a transformative solution, enhancing CUR's stability in aqueous solutions. Multisensing approaches involving fluorescence, electrochemistry, and NMR spectroscopy were employed, demonstrating CyDngs' pivotal role in CUR detection. Langmuir analysis revealed a binding constant of 1.4 × 10 M for CyDngs, highlighting their effectiveness over native β-CyDs. The study emphasized CyDngs' superiority in stabilizing CUR and enabling reliable and sensitive detection with very diverse methods.
姜黄素（CUR）是一种来自姜黄的多酚类物质，具有多种药用特性。然而，其不稳定性给检测带来了挑战。基于环糊精的纳米凝胶（CyDngs）提供了一种变革性的解决方案，可增强CUR在水溶液中的稳定性。采用了涉及荧光、电化学和核磁共振光谱的多传感方法，证明了CyDngs在CUR检测中的关键作用。朗缪尔分析显示CyDngs的结合常数为1.4×10 M，突出了它们相对于天然β-环糊精的有效性。该研究强调了CyDngs在稳定CUR以及通过多种方法实现可靠且灵敏检测方面的优越性。
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