基于环糊精的纳米凝胶用于姜黄素的稳定化和传感

Cyclodextrin-Based Nanogels for Stabilization and Sensing of Curcumin.

作者信息

Casulli Maria Antonietta, Yan Ruyu, Takeuchi Satomi, Cesari Andrea, Mancin Fabrizio, Hayashita Takashi, Hashimoto Takeshi, Taurino Irene

机构信息

Micro and Nano-Systems (MNS), Department of Electrical Engineering (ESAT), Katholieke Universiteit Leuven (KU Leuven), 3001 Leuven, Belgium.

Graduate School of Science and Technology, Department of Materals and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioi-cho, Chiyoda-ku, Tokyo 102-8554, Japan.

出版信息

ACS Appl Nano Mater. 2024 Aug 27;7(17):20153-20162. doi: 10.1021/acsanm.4c02972. eCollection 2024 Sep 13.

Curcumin (CUR), a polyphenolic substance from turmeric, displays diverse medicinal properties. However, its instability poses challenges in detection. Cyclodextrin-based nanogels (CyDngs) offer a transformative solution, enhancing CUR's stability in aqueous solutions. Multisensing approaches involving fluorescence, electrochemistry, and NMR spectroscopy were employed, demonstrating CyDngs' pivotal role in CUR detection. Langmuir analysis revealed a binding constant of 1.4 × 10 M for CyDngs, highlighting their effectiveness over native β-CyDs. The study emphasized CyDngs' superiority in stabilizing CUR and enabling reliable and sensitive detection with very diverse methods.