Aliakbarian Mohsen, Jazinaki Mostafa Shahraki, Bahari Hossein, Rashidmayvan Mohammad, Golafrouz Haniyeh, Khodashahi Rozita, Pahlavani Naseh
Transplant Research Center, Clinical Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
Curr Dev Nutr. 2024 Aug 13;8(9):104438. doi: 10.1016/j.cdnut.2024.104438. eCollection 2024 Sep.
Propolis, a natural resin produced by bees, has been studied for its potential effects on liver enzymes and obesity indices. However, a meta-analysis is necessary to comprehensively understand the impact of propolis on obesity and liver function.
This meta-analysis of randomized controlled trials (RCTs) sought to evaluate the effects of propolis consumption on liver enzymes and obesity indices in adults.
A systematic literature search up to December 2023 was completed in PubMed/Medline, Scopus, and Web of Science, to identify eligible RCTs. Heterogeneity tests of the selected trials were performed using the statistic. Random-effects models were assessed on the basis of the heterogeneity tests, and pooled data were determined as weighted mean differences (WMDs) with a 95% confidence interval (CI).
A pooled analysis of 24 trials showed that propolis consumption led to a significant reduction in alanine aminotransferase (ALT) (WMD: -2.58; 95% CI: -4.64, -0.52; = 0.01), aspartate aminotransferase (AST) (WMD: -1.84; 95% CI: -3.01, -0.67; = 0.002), and alkaline phosphatase (ALP) (WMD: -24.90; 95% CI: -42.13, -7.67; = 0.005) in comparison with the control group. However, there were no significant effects on gamma-glutamyl transferase (GGT), body weight, BMI (in kg/m), fat mass, body fat percentage, fat-free mass, adiponectin, waist circumference, hip circumference, and waist-hip ratio in comparison with the control group.
We discovered that consuming propolis can lead to a significant decrease in ALT, AST, and ALP levels, without causing significant changes in GGT, anthropometric indices, and adiponectin levels. However, future well-designed RCTs with large numbers of participants and extended durations, focusing on precise propolis dosage and ingredients, are necessary.
蜂胶是蜜蜂产生的一种天然树脂，其对肝脏酶和肥胖指数的潜在影响已得到研究。然而，有必要进行一项荟萃分析以全面了解蜂胶对肥胖和肝功能的影响。
这项对随机对照试验（RCT）的荟萃分析旨在评估成人食用蜂胶对肝脏酶和肥胖指数的影响。
截至2023年12月，在PubMed/Medline、Scopus和科学网完成了系统的文献检索，以确定符合条件的随机对照试验。使用 统计量对所选试验进行异质性检验。在异质性检验的基础上评估随机效应模型，并将汇总数据确定为加权平均差（WMD）及其95%置信区间（CI）。
对24项试验的汇总分析表明，与对照组相比，食用蜂胶可使丙氨酸氨基转移酶（ALT）（WMD：-2.58；95%CI：-4.64，-0.52； = 0.01）、天冬氨酸氨基转移酶（AST）（WMD：-1.84；95%CI：-3.01，-0.67； = 0.002）和碱性磷酸酶（ALP）（WMD：-24.90；95%CI：-42.13，-7.67； = 0.005）显著降低。然而，与对照组相比，对γ-谷氨酰转移酶（GGT）、体重、体重指数（kg/m）、脂肪量、体脂百分比、去脂体重、脂联素、腰围、臀围和腰臀比没有显著影响。
我们发现食用蜂胶可导致ALT、AST和ALP水平显著降低，而不会引起GGT、人体测量指标和脂联素水平的显著变化。然而，未来需要进行设计良好、参与者众多且持续时间更长的随机对照试验，重点关注精确的蜂胶剂量和成分。
