Gheflati Alireza, Dehnavi Zahra, Ghannadzadeh Yazdi Aliyeh, Khorasanchi Zahra, Raeisi-Dehkordi Hamidreza, Ranjbar Golnaz
Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Avicenna J Phytomed. 2021 Nov-Dec;11(6):551-565. doi: 10.22038/AJP.2021.18046.
Propolis is a sticky, resinous substance produced by honeybees from various plants. Various biological properties of propolis and its extracts have been recognized in previous studies including the antiseptic, anti-inflammatory, antioxidant, antiviral, hepatoprotective, antitumor, antibacterial and antimycotic properties. This study aimed to summarize the effect of propolis on metabolic parameters in human adults using systematic review and meta-analysis.
A comprehensive systematic search was performed in ISI Web of Science, PubMed, Scopus, and Google Scholar up to July 2020 for controlled clinical trials evaluating the impact of propolis on lipid profile and liver enzyme biomarkers. A random effects model was used to calculate the weighted mean difference (WMD) and 95% confidence interval (CI) as the difference between the mean for the intervention and control groups.
The present meta-analysis included six randomized controlled trials. There was significant reduction in Aspartate Aminotransferase (AST) in comparison to the control groups (WMD=-2.01; 95% CI: -3.93--0.10; p=0.039). However, a non-significant effect was observed in Triglycerides (TG), Total cholesterol (TC), low-density lipoprotein (LDL), High-density lipoprotein (HDL) (WMD=-0.05 mg/dl; 95% CI: -0.27-0.18; p=0.688; WMD=7.08 mg/dl; 95% CI: -37.31-51.46; p=0.755; WMD=-0.94 mg/dl; 95% CI: -6.64-4.77; p=0.747; WMD=3.14 mg/dl; 95% CI: -1.84-8.13; p=0.216, respectively).
Current meta-analysis revealed that propolis supplementation can reduce AST; nevertheless, there was no significant effect on lipid profile indices and ALT.
蜂胶是蜜蜂从各种植物中采集并加工而成的一种粘性树脂状物质。此前的研究已证实蜂胶及其提取物具有多种生物学特性，包括防腐、抗炎、抗氧化、抗病毒、保肝、抗肿瘤、抗菌和抗真菌特性。本研究旨在通过系统评价和荟萃分析总结蜂胶对成年人代谢参数的影响。
截至2020年7月，在科学网（ISI Web of Science）、PubMed、Scopus和谷歌学术（Google Scholar）数据库中进行全面系统检索，查找评估蜂胶对血脂谱和肝酶生物标志物影响的对照临床试验。采用随机效应模型计算加权平均差（WMD）和95%置信区间（CI），作为干预组与对照组均值之间的差值。
本荟萃分析纳入了六项随机对照试验。与对照组相比，天冬氨酸转氨酶（AST）显著降低（WMD = -2.01；95% CI：-3.93 - -0.10；p = 0.039）。然而，甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）未观察到显著效果（WMD = -0.05 mg/dl；95% CI：-0.27 - 0.18；p = 0.688；WMD = 7.08 mg/dl；95% CI：-37.31 - 51.46；p = 0.755；WMD = -0.94 mg/dl；95% CI：-6.64 - 4.77；p = 0.747；WMD = 3.14 mg/dl；95% CI：-1.84 - 8.13；p = 0.216）。
当前的荟萃分析表明，补充蜂胶可降低AST；然而，对血脂谱指标和丙氨酸转氨酶（ALT）无显著影响。
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