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首次心肌梗死后40天内进行的运动试验的预后价值

[Prognostic value of the exercise test performed less than 40 days after the first infarction].

作者信息

Saint-Pierre A, Diab M, Saradarian W, Noblecourt P, Milon H, Jacquemet C, Chapelier J, Robert M

出版信息

Arch Mal Coeur Vaiss. 1985 Jun;78(6):861-8.

PMID:3929715
Abstract

Stress testing was performed in 159 men (mean age 49.83 years) between the 10th and 40th day after primary myocardial infarction. The average work achieved was 79 watts with a heart rate of 121/min, systolic blood pressure of 169 mmHg, and a double product of 20 544. The result was negative in 53 p. 100 of cases, and positive in 47 p. 100: the positive response was ischaemic in 23 p. 100 and non ischaemic in 24 p. 100 of cases. In the 2 years which followed, post-infarction angina was observed in 44 p. 100 of cases (14 p. 100 unstable angina), recurrent infarction in 7 p. 100 and death in 4 p. 100; coronary angiography was performed in 19 p. 100 of cases and coronary bypass surgery in 6 p. 100; 53 p. 100 of patients remained asymptomatic. The difference in predictive value between negative stress testing for an asymptomatic outcome and a positive ischaemic test for post-infarction angina and bypass surgery was important (p less than 0.001). The correlation was not as significant for death and recurrent infarction. The non-ischaemic positive result was of less value. There was no relationship to age but the prediction was more accurate in postero-inferior (p less than 0.001) than anterior infarction (p less than 0.05). The timing of the test affected the performance and patient comfort but had less influence on the results. Nevertheless, the predictive values were less good at 2 weeks than later on and significantly improved when testing was performed between the 10th and 11th week. However, early stress testing was valuable for identifying high risk subgroups.

摘要

在初次心肌梗死后第10天至第40天之间,对159名男性(平均年龄49.83岁)进行了负荷试验。平均做功量为79瓦,心率为121次/分钟,收缩压为169毫米汞柱,双乘积为20544。结果在53%的病例中为阴性,在47%的病例中为阳性:在23%的病例中阳性反应为缺血性,在24%的病例中为非缺血性。在随后的2年中,44%的病例出现了梗死后心绞痛(14%为不稳定型心绞痛),7%的病例出现了再梗死,4%的病例死亡;19%的病例进行了冠状动脉造影,6%的病例进行了冠状动脉搭桥手术;53%的患者无症状。无症状结局的阴性负荷试验与梗死后心绞痛和搭桥手术的阳性缺血试验之间的预测价值差异显著(p<0.001)。死亡和再梗死的相关性不那么显著。非缺血性阳性结果的价值较小。与年龄无关,但下后壁梗死(p<0.001)的预测比前壁梗死(p<0.05)更准确。试验时间影响检查效果和患者舒适度,但对结果影响较小。然而,2周时的预测价值不如后期,在第10周和第11周之间进行试验时显著改善。然而,早期负荷试验对于识别高危亚组很有价值。

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