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Noncontractile Stem Cell-Cardiomyocytes Preserve Post-Infarction Heart Function.

作者信息

Karbassi Elaheh, Yoo Dasom, Martinson Amy M, Yang Xiulan, Reinecke Hans, Regnier Michael, Murry Charles E

机构信息

Institute for Stem Cell and Regenerative Medicine (E.K., D.Y., A.M.M., X.Y., H.R., M.R., C.E.M.), University of Washington, Seattle.

Center for Cardiovascular Biology (E.K., D.Y., A.M.M., X.Y., H.R., M.R., C.E.M.), University of Washington, Seattle.

出版信息

Circ Res. 2024 Oct 11;135(9):967-969. doi: 10.1161/CIRCRESAHA.124.325133. Epub 2024 Sep 19.

DOI:10.1161/CIRCRESAHA.124.325133
PMID:39297201
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11465756/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf62/11465756/e0bd11077fb1/res-135-967-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf62/11465756/e0bd11077fb1/res-135-967-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf62/11465756/e0bd11077fb1/res-135-967-g001.jpg

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bioRxiv. 2025 Mar 19:2025.03.18.644054. doi: 10.1101/2025.03.18.644054.

本文引用的文献

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Contractile Force of Transplanted Cardiomyocytes Actively Supports Heart Function After Injury.移植的心肌细胞的收缩力在损伤后积极支持心脏功能。
Circulation. 2022 Oct 11;146(15):1159-1169. doi: 10.1161/CIRCULATIONAHA.122.060124. Epub 2022 Sep 8.
2
Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment.肌节功能激活了一个依赖 p53 的 DNA 损伤反应，该反应促进了多倍体形成，并限制了体内细胞的植入。
Cell Rep. 2021 May 4;35(5):109088. doi: 10.1016/j.celrep.2021.109088.
3
Human embryonic stem cell-derived cardiomyocytes restore function in infarcted hearts of non-human primates.
人类胚胎干细胞衍生的心肌细胞可恢复非人灵长类动物梗死心脏的功能。
Nat Biotechnol. 2018 Aug;36(7):597-605. doi: 10.1038/nbt.4162. Epub 2018 Jul 2.
4
Emerging Concepts in Paracrine Mechanisms in Regenerative Cardiovascular Medicine and Biology.再生心血管医学与生物学中旁分泌机制的新兴概念
Circ Res. 2016 Jan 8;118(1):95-107. doi: 10.1161/CIRCRESAHA.115.305373.
5
Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts.源自人类胚胎干细胞的心肌细胞在促存活因子作用下增强梗死大鼠心脏的功能。
Nat Biotechnol. 2007 Sep;25(9):1015-24. doi: 10.1038/nbt1327. Epub 2007 Aug 26.