HHMI at Rockefeller University, New York, NY 10065.
Proc Natl Acad Sci U S A. 2024 Sep 24;121(39):e2415550121. doi: 10.1073/pnas.2415550121. Epub 2024 Sep 19.
The 2024 Lasker~DeBakey Clinical Medical Research Award has been given to Joel Habener and Svetlana Mojsov for their discovery of a new hormone GLP-1(7-37) and to Lotte Knudsen for her role in developing sustained acting versions of this hormone as a treatment for obesity. Each of the three had a distinct set of skills that made this advance possible; Habener is an endocrinologist and molecular biologist, Mojsov is a peptide chemist, and Knudsen is a pharmaceutical scientist. Their collective efforts have done what few thought possible-the development of highly effective medicines for reducing weight. Their research has also solved a mystery that began more than a century ago.
2024 年拉斯克-德贝基临床医学研究奖授予 Joel Habener、Svetlana Mojsov，以表彰他们发现了一种新的激素 GLP-1(7-37)，以及 Lotte Knudsen 在开发这种激素的长效版本作为肥胖症治疗方法方面所做的贡献。这三位科学家都有独特的技能，使得这一进展成为可能；Habener 是内分泌学家和分子生物学家，Mojsov 是肽化学家，Knudsen 是药物科学家。他们的共同努力实现了很少有人认为可能的事情——开发出高效的减肥药。他们的研究还解决了一个一个多世纪前就开始的谜团。
