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[呋喃西林引起的过敏性接触性皮炎]

[Allergic contact dermatitis due to Furacin®].

作者信息

Moreno-Lozano Lucía, de Aramburu-Mera Teresa, Bermúdez-Hormigo Carmen

机构信息

Servicio de Alergología, Hospital Punta Europa, Algeciras (Cádiz), España.

出版信息

Rev Alerg Mex. 2024 Jun 30;71(2):128-130. doi: 10.29262/ram.v71i2.1246.

Abstract

BACKGROUND

Allergic sensitization to topical antimicrobial treatments is a well-known problem. Furacin® is one of the most widely used in our environment. It contains 0.2% nitrofurazone and polyethylene glycol (PEG) as a vehicle.

CASE REPORT

57-year-old male with no history of interest. He presented skin rash, blisters, and serous exudate 2-3 days after starting treatment with Furacin® (applied to an infected skin wound). Epicutaneous tests were performed with a true test battery, nitrofurantoin 1% in petrolatum, PEG15000 and 4000 1% in petrolatum, pure PEG 400, PEG monomethyl ether 350 1% in water. Positive result at 96 hours for nitrofurantoin.

CONCLUSION

Nitrofurazone is widely used as a topical antibiotic because of its bactericidal spectrum. It (including its excipients) should be considered in case of adverse reactions after application.

摘要

背景

对抗菌外用治疗产生过敏致敏是一个众所周知的问题。呋西林是我们环境中使用最广泛的药物之一。它含有0.2%的呋喃西林和作为载体的聚乙二醇(PEG)。

病例报告

一名57岁男性,无相关病史。在开始使用呋西林(用于感染的皮肤伤口)治疗2 - 3天后,他出现了皮疹、水疱和浆液性渗出物。使用真正的测试组进行了皮肤试验,包括凡士林基质中1%的呋喃妥因、凡士林基质中1%的PEG15000和4000、纯PEG 400、水中1%的聚乙二醇单甲醚350。呋喃妥因在96小时时呈阳性结果。

结论

呋喃西林因其杀菌谱而被广泛用作外用抗生素。在应用后出现不良反应的情况下,应考虑它(包括其辅料)。

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