The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA.
The Newman Center for Human Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, Missouri, USA.
Ann N Y Acad Sci. 2024 Oct;1540(1):13-20. doi: 10.1111/nyas.15224. Epub 2024 Sep 19.
Studies of the human microbiome are progressing rapidly but have largely focused on populations living in high-income countries. With increasing evidence that the microbiome contributes to the pathogenesis of diseases that affect infants, children, and adults in low- and middle-income countries (LMICs), and with profound and rapid ongoing changes occurring in our lifestyles and biosphere, understanding the origins of and developing microbiome-directed therapeutics for treating a number of global health challenges requires the development of programs for studying human microbial ecology in LMICs. Here, we discuss how the establishment of long-term human microbial observatory programs in selected LMICs could provide one timely approach.
人类微生物组的研究正在迅速推进，但主要集中在高收入国家的人群上。越来越多的证据表明，微生物组有助于引发影响低收入和中等收入国家（LMICs）的婴儿、儿童和成年人的疾病的发病机制，并且我们的生活方式和生物圈正在发生深刻而迅速的变化，因此，了解微生物组的起源并开发针对许多全球健康挑战的微生物组导向治疗方法，需要在 LMICs 中制定研究人类微生物生态学的计划。在这里，我们讨论了如何在选定的 LMICs 中建立长期的人类微生物观测站计划，这可能是一种及时的方法。
