镍催化、氨基喹啉导向的未活化烯烃与有机硼酸和邻氨基苯甲酸酯的化学及区域选择性碳胺化反应
Nickel-Catalyzed, Aminoquinoline-Directed Chemo- and Regioselective Carboamination of Unactivated Olefins with Organoboronic Acids and Anthranils.
作者信息
Xie Zhongke, Cui Yushan, Xing Jiale, Gao Yang, Huo Yanping, Li Xianwei, Chen Qian
机构信息
School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China.
Jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory, Jieyang 515200, China.
出版信息
J Org Chem. 2024 Oct 4;89(19):14151-14163. doi: 10.1021/acs.joc.4c01536. Epub 2024 Sep 19.
A nickel-catalyzed three-component carboamination of unactivated alkenes with organoboronic acids and anthranils has been achieved for the expedient synthesis of δ-aryl and γ-amino acid derivatives. The 8-aminoquinoline (AQ) directing group is crucial for the success of the reaction, and anthranil serves as an arylnitrene precursor in this conversion. This method features mild reaction conditions, good chemo- and regioselectivity, and a broad substrate scope with good functional group tolerance.
已实现镍催化未活化烯烃与有机硼酸和邻氨基苯甲酰亚胺的三组分碳胺化反应，用于便捷合成δ-芳基和γ-氨基酸衍生物。8-氨基喹啉（AQ）导向基团对反应成功至关重要，且邻氨基苯甲酰亚胺在该转化中作为芳基氮烯前体。该方法具有反应条件温和、化学和区域选择性良好以及底物范围广且官能团耐受性好的特点。
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