National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Chinese Medicine, Nanchang, 330006, China.
Department of Pharmacy, The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, 330006, China.
Nitric Oxide. 2024 Nov 1;152:48-57. doi: 10.1016/j.niox.2024.09.005. Epub 2024 Sep 19.
Nitric oxide (NO) plays a crucial role as a messenger or effector in the body, yet it presents a dual impact on cardio-cerebrovascular health. Under normal physiological conditions, NO exhibits vasodilatory effects, regulates blood pressure, inhibits platelet aggregation, and offers neuroprotective actions. However, in pathological situations, excessive NO production contributes to or worsens inflammation within the body. Moreover, NO may combine with reactive oxygen species (ROS), generating harmful substances that intensify physical harm. This paper succinctly reviews pertinent literature to clarify the in vivo and in vitro origins of NO, its regulatory function in the cardio-cerebrovascular system, and the advantages and disadvantages associated with NO donor drugs, NO delivery systems, and vascular stent materials for treating cardio-cerebrovascular disease. The findings provide a theoretical foundation for the application of NO in cardio-cerebrovascular diseases.
一氧化氮（NO）作为体内的信使或效应物发挥着至关重要的作用，但它对心脑血管健康具有双重影响。在正常生理条件下，NO 具有血管舒张作用，调节血压，抑制血小板聚集，并具有神经保护作用。然而，在病理情况下，过量的 NO 产生会导致或加重体内炎症。此外，NO 可能与活性氧（ROS）结合，生成有害物质，加剧身体伤害。本文简要综述了相关文献，以阐明体内和体外 NO 的来源、它在心血管系统中的调节功能，以及用于治疗心脑血管疾病的 NO 供体药物、NO 输送系统和血管支架材料的优缺点。这些发现为 NO 在心脑血管疾病中的应用提供了理论基础。
