Zhang Yihong, Liu Wanling, Wang Xiaoyu, Liu Yufeng, Wei Hui
College of Engineering and Applied Sciences, Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University, Nanjing, Jiangsu, 210023, China.
Department of Chemistry and Material Science, College of Science, Nanjing Forestry University, Nanjing, Jiangsu, 210037, China.
Small. 2023 Mar;19(13):e2204809. doi: 10.1002/smll.202204809. Epub 2022 Oct 3.
Cardio- and cerebrovascular diseases are two major vascular-related diseases that lead to death worldwide. Reactive oxygen species (ROS) play a vital role in the occurrence and exacerbation of diseases. Excessive ROS induce cellular context damage and lead to tissue dysfunction. Nanozymes, as emerging enzyme mimics, offer a unique perspective for therapy through multifunctional activities, achieving essential results in the treatment of ROS-related cardio- and cerebrovascular diseases by directly scavenging excess ROS or regulating pathologically related molecules. This review first introduces nanozyme-enabled therapeutic mechanisms at the cellular level. Then, the therapies for several typical cardio- and cerebrovascular diseases with nanozymes are discussed, mainly including cardiovascular diseases, ischemia reperfusion injury, and neurological disorders. Finally, the challenges and outlooks for the application of nanozymes are also presented. This review will provide some instructive perspectives on nanozymes and promote the development of enzyme-mimicking strategies in cardio- and cerebrovascular disease therapy.
心血管疾病和脑血管疾病是导致全球死亡的两种主要血管相关疾病。活性氧（ROS）在疾病的发生和加重中起着至关重要的作用。过量的ROS会导致细胞环境损伤并导致组织功能障碍。纳米酶作为新兴的酶模拟物，通过多功能活性为治疗提供了独特的视角，通过直接清除过量的ROS或调节病理相关分子，在治疗与ROS相关的心血管和脑血管疾病方面取得了重要成果。本文综述首先介绍了纳米酶在细胞水平上的治疗机制。然后，讨论了纳米酶对几种典型心血管和脑血管疾病的治疗，主要包括心血管疾病、缺血再灌注损伤和神经疾病。最后，还介绍了纳米酶应用面临的挑战和前景。本综述将为纳米酶提供一些有启发性的观点，并促进酶模拟策略在心血管和脑血管疾病治疗中的发展。
