Alzheimer's Disease Research Unit, Yale School of Medicine, New Haven, Connecticut.
Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut.
J Nucl Med. 2024 Nov 1;65(11):1782-1785. doi: 10.2967/jnumed.124.267419.
Simplified methods of acquisition and quantification would facilitate the use of synaptic density imaging in multicenter and longitudinal studies of Alzheimer disease (AD). We validated a simplified tissue-to-reference ratio method using SUV ratios (SUVRs) for estimating synaptic density with [C]UCB-J PET. Participants included 31 older adults with AD and 16 with normal cognition. The distribution volume ratio (DVR) using simplified reference tissue model 2 was compared with SUVR at short scan windows using a whole-cerebellum reference region. Synaptic density was reduced in AD participants using DVR or SUVR. SUVR using later scan windows (60-90 or 70-90 min) was minimally biased, with the strongest correlation with DVR. Effect sizes using SUVR at these late time windows were minimally reduced compared with effect sizes with DVR. A simplified tissue-to-reference method may be useful for multicenter and longitudinal studies seeking to measure synaptic density in AD.
简化的获取和量化方法将有助于在阿尔茨海默病（AD）的多中心和纵向研究中使用突触密度成像。我们使用 [C]UCB-J PET 验证了一种使用 SUV 比（SUVR）估计突触密度的简化组织与参考比方法。参与者包括 31 名患有 AD 的老年人和 16 名认知正常的老年人。使用简化的参考组织模型 2 的分布容积比（DVR）与使用小脑全参考区域的短扫描窗中的 SUVR 进行比较。使用 DVR 或 SUVR 可以检测到 AD 参与者的突触密度降低。使用较晚扫描窗（60-90 或 70-90 分钟）的 SUVR 最小偏倚，与 DVR 的相关性最强。与使用 DVR 的效应量相比，使用这些较晚时间窗的 SUVR 的效应量仅略有降低。简化的组织与参考方法可能对寻求在 AD 中测量突触密度的多中心和纵向研究有用。
