School of Nursing and Rehabilitation, Shandong University, Jinan, 250000, Shandong, China.
Department of Nursing, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250000, China.
Sci Rep. 2024 Sep 19;14(1):21880. doi: 10.1038/s41598-024-71488-y.
Inflammation plays an important role in depression, and the neutrophil-to-albumin ratio (NPAR) is a cost-effective and readily available novel biomarker of inflammation. The association between NPAR and depression is unclear; therefore, to assess the relationship between NPAR and depression, we conducted a cross-sectional study of 33,768 participants ≥ 18 years of age from the 2005-2018 NHANES database. NPAR was calculated as Neutrophil percentage (in total WBC count) (%) × 100/Albumin (g/dL). Multivariate logistic regression models were used to test the independent association between NPAR and depression, adjusting for demographic factors, education, smoking status, alcohol consumption, hypertension, diabetes mellitus, body mass index, the ratio of income to poverty, and history of cardiovascular disease. Results showed that NPAR was significantly and positively associated with depression. When NPAR were analyzed as a categorical variable, there was a 20% increase in the prevalence of depression in the quartile with the highest NPAR compared to the quartile with the lowest NPAR (OR 1.20[95% CI 1.06, 1.36]). Smoothed curve fitting and threshold effect analyses also showed a positive association between NPAR and depression, with an inflection point for threshold and saturation effects of 12.65. NPAR was positively associated with the likelihood of developing depression when NPAR > 12.65 (OR 1.06[95% CI 1.04, 1.09]). The results of subgroup analyses and interaction tests indicated that smoking status had a significant effect on the relationship between NPAR and depression (P < 0.05). Our study reveals a positive association between NPAR levels and depression, suggesting that higher NPAR levels are associated with an increased likelihood of developing depression.
炎症在抑郁症中起着重要作用，中性粒细胞与白蛋白比值（NPAR）是一种具有成本效益且易于获得的新型炎症生物标志物。NPAR 与抑郁症之间的关系尚不清楚；因此，为了评估 NPAR 与抑郁症之间的关系，我们对 2005-2018 年 NHANES 数据库中 33768 名年龄≥18 岁的参与者进行了横断面研究。NPAR 计算方法为中性粒细胞百分比（在总白细胞计数中）（%）×100/白蛋白（g/dL）。多变量逻辑回归模型用于测试 NPAR 与抑郁症之间的独立关联，调整了人口统计学因素、教育程度、吸烟状况、饮酒状况、高血压、糖尿病、体重指数、收入与贫困比例以及心血管疾病史。结果表明，NPAR 与抑郁症显著正相关。当 NPAR 作为分类变量进行分析时，与 NPAR 最低四分位数相比，NPAR 最高四分位数的抑郁症患病率增加了 20%（OR 1.20[95%CI 1.06, 1.36]）。平滑曲线拟合和阈值效应分析也显示了 NPAR 与抑郁症之间的正相关关系，阈值和饱和效应的拐点为 12.65。当 NPAR>12.65 时，NPAR 与发生抑郁症的可能性呈正相关（OR 1.06[95%CI 1.04, 1.09]）。亚组分析和交互检验的结果表明，吸烟状况对 NPAR 与抑郁症之间的关系有显著影响（P<0.05）。我们的研究揭示了 NPAR 水平与抑郁症之间的正相关关系，表明较高的 NPAR 水平与发生抑郁症的可能性增加有关。
