University City Hospital, Affiliated Hospital of Shandong University of Chinese Medicine, Jinan, China.
Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Sci Rep. 2024 Apr 29;14(1):9809. doi: 10.1038/s41598-024-60322-0.
Current research has shown an increasing acceptance of interventions for depression through dietary modifications. However, whether composite dietary antioxidant index (CDAI) is associated with depression and all-cause mortality in middle-aged and elderly population remains unknown. This study aimed to explore those associations in American middle-aged and elderly population. Weighted logistic regression models and weighted Cox proportional hazard regression models were used to assess the association of CDAI, covariates, depression, and all-cause mortality, respectively. The stability of the results was also determined by a linear trend test based on CDAI quintiles. Restricted cubic spline curves were employed to test for non-linear relationships. In the model adjusted for all covariates, significant associations were found with the ORs (95% CI) for CDAI and depression [0.77 (0.67, 0.89)] and the HRs (95% CI) for CDAI with all-cause mortality[0.91 (0.83, 1.00)]. Upon conducting restricted cubic spline curves, we found that the association between CDAI and depression was linear, whereas the association between CDAI and all-cause mortality was non-linear with an inflection point of -0.19. Statistical significance was only found before the inflection point. In this study of middle-aged and elderly Americans, CDAI was linearly negatively associated with depression and non-linearly negatively associated with all-cause mortality.
目前的研究表明，通过饮食调整，人们越来越接受抑郁症的干预措施。然而，复合饮食抗氧化指数（CDAI）是否与中年和老年人群的抑郁症和全因死亡率有关尚不清楚。本研究旨在探讨美国中年和老年人群中这些关联。使用加权逻辑回归模型和加权 Cox 比例风险回归模型分别评估 CDAI、协变量、抑郁症和全因死亡率之间的相关性。还通过基于 CDAI 五分位数的线性趋势检验来确定结果的稳定性。采用限制性立方样条曲线来检验非线性关系。在调整所有协变量的模型中，CDAI 与抑郁症的比值比（95%CI）[0.77（0.67，0.89）]和 CDAI 与全因死亡率的风险比（95%CI）[0.91（0.83，1.00）]之间存在显著关联。进行限制性立方样条曲线后，我们发现 CDAI 与抑郁症之间的关联呈线性，而 CDAI 与全因死亡率之间的关联呈非线性，拐点为-0.19。仅在拐点之前发现具有统计学意义。在这项对美国中年和老年人群的研究中，CDAI 与抑郁症呈线性负相关，与全因死亡率呈非线性负相关。
