用干酪乳杆菌和短小棒状杆菌引发库普弗细胞产生细胞毒性因子。
Cytotoxic factor production by Kupffer cells elicited with Lactobacillus casei and Corynebacterium parvum.
作者信息
Hashimoto S, Seyama Y, Yokokura T, Mutai M
出版信息
Cancer Immunol Immunother. 1985;20(2):117-21. doi: 10.1007/BF00205677.
The ability of Kupffer cells, spleen macrophages, pulmonary macrophages, and peritoneal macrophages (PM) to produce cytotoxic factor (CTF) was investigated in vitro. The production of CTF by Kupffer cells elicited with Corynebacterium parvum (CP) or Lactobacillus casei YIT9018 (LC9018) was higher than that of spleen, pulmonary macrophages, or PM. In addition, oxygen radical (OR) production by Kupffer cells or PM was measured. The production of OR by Kupffer cells or PM was significantly augmented by i.v. or i.p. injection of LC9018 or CP. No significant correlation was observed between the increase in OR production by Kupffer cells or PM and CTF production by Kupffer cells or PM elicited with either organism. It was suggested that activated Kupffer cells may be one important source of CTF production in serum and that the CTF-producing macrophages may be different from the OR-producing macrophages.
体外研究了库普弗细胞、脾巨噬细胞、肺巨噬细胞和腹腔巨噬细胞（PM）产生细胞毒性因子（CTF）的能力。用短小棒状杆菌（CP）或干酪乳杆菌YIT9018（LC9018）刺激的库普弗细胞产生CTF的能力高于脾、肺巨噬细胞或PM。此外，还检测了库普弗细胞或PM产生氧自由基（OR）的情况。静脉内或腹腔内注射LC9018或CP可显著增强库普弗细胞或PM产生OR的能力。在用这两种生物体刺激的情况下，库普弗细胞或PM产生OR的增加与库普弗细胞或PM产生CTF之间未观察到显著相关性。提示活化的库普弗细胞可能是血清中CTF产生的一个重要来源，且产生CTF的巨噬细胞可能与产生OR的巨噬细胞不同。
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