Department of Pediatric Gastroenterology, Adana City Training and Research Hospital, Adana, Turkey.
Department of Pediatric Hematology, Adana City Training and Research Hospital, Adana, Turkey.
J Paediatr Child Health. 2024 Nov;60(11):737-740. doi: 10.1111/jpc.16674. Epub 2024 Sep 19.
Coeliac disease (CD) is an autoimmune enteropathy that develops upon ingestion of food containing gluten. The established link between ABO blood groups and numerous infectious and non-infectious illnesses prompted this investigation into blood group distribution and its relationship with dietary compliance among children diagnosed with CD.
In this retrospective study, patients with CD who were followed for ≥1 year at the paediatric gastroenterology outpatient clinic of our hospital were evaluated. History, physical examination and coeliac serology results were reviewed for each patient. Patients were divided into two groups based on self-reported compliance to a gluten-free diet: diet-adherent and non-diet-adherent. Patient and control groups were examined in terms of ABO blood groups.
A total of 177 patients with CD were included in the study. A control group of 211 age- and sex-matched children without any chronic disease who had undergone blood group testing for various reasons was included for comparison. A total of 65% (n = 115) of the patients were girls, and 35% (n = 62) were boys. No significant relationship was found between CD diagnosis and ABO blood groups among patients (P = 0.559). Furthermore, the dietary compliance status of the patients was not associated with any specific blood group (P = 0.951).
No notable difference was found between patients with CD with or without gluten-free diet compliance in terms of the distribution of ABO blood groups and Rhesus (Rh) factor. Therefore, it can be inferred that all blood groups and subgroups carry an equal risk for CD.
乳糜泻（CD）是一种自身免疫性肠病，在摄入含有麸质的食物后发生。ABO 血型与众多感染性和非传染性疾病之间的既定联系促使我们对血型分布进行了调查，并研究了其与确诊为 CD 的儿童饮食依从性之间的关系。
在这项回顾性研究中，我们评估了在我院儿科胃肠病门诊接受随访时间≥1 年的 CD 患者。对每位患者的病史、体格检查和乳糜泻血清学结果进行了回顾。根据患者自述对无麸质饮食的依从情况，将患者分为饮食依从组和非饮食依从组。检查了患者和对照组的 ABO 血型。
本研究共纳入 177 例 CD 患者。纳入了 211 名因各种原因接受血型检测且无任何慢性疾病的年龄和性别相匹配的儿童作为对照组进行比较。患者中 65%（n=115）为女性，35%（n=62）为男性。患者中 CD 诊断与 ABO 血型之间无显著相关性（P=0.559）。此外，患者的饮食依从状况与任何特定血型均无关联（P=0.951）。
在有无无麸质饮食依从的 CD 患者中，ABO 血型和 Rh 因子分布无明显差异。因此，可以推断所有血型及其亚组发生 CD 的风险相等。
