Arun Arya, Tay Hui Min, Beer Paul D
Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK.
Department of Chemistry, University of Oxford, Rodney Porter Building, Sibthorp Road, Oxford OX1 3QU, UK.
Chem Commun (Camb). 2024 Oct 15;60(83):11849-11863. doi: 10.1039/d4cc03916e.
The ever-increasing interest directed towards the construction of host architectures capable of the strong and selective recognition of various ionic species of biological, medical and environmental importance has identified mechanically interlocked molecules (MIMs), such as rotaxanes and catenanes, as potent host systems, owing to their unique three-dimensional topologically preorganised cavity recognition environments. Ion-pair receptors are steadily gaining prominence over monotopic receptor analogues due to their enhanced binding strength and selectivity, demonstrated primarily through acyclic and macrocyclic heteroditopic host systems. Exploiting the mechanical bond for ion-pair recognition through the strategic design of neutral heteroditopic MIMs offers exciting opportunities to accomplish potent and effective binding while mitigating competing interactions from the bulk solvent and counter-ions. This review details the design and ion-pair recognition capabilities of rotaxanes and catenanes employing hydrogen bonding (HB) and halogen bonding (XB) motifs, providing valuable insight into the burgeoning field and inspiration for future research.
人们对构建能够强烈且选择性地识别具有生物学、医学和环境重要性的各种离子物种的主体结构的兴趣与日俱增，这使得机械互锁分子（MIMs），如轮烷和索烃，成为了强大的主体体系，这归因于它们独特的三维拓扑预组织腔识别环境。由于离子对受体具有增强的结合强度和选择性，主要通过无环和大环异二价主体体系得以证明，因此它们相对于单位点受体类似物正逐渐受到更多关注。通过中性异二价MIMs的策略性设计，利用机械键进行离子对识别，为实现强效且有效的结合同时减轻来自大量溶剂和抗衡离子的竞争相互作用提供了令人兴奋的机会。本综述详细介绍了采用氢键（HB）和卤键（XB）基序的轮烷和索烃的设计及离子对识别能力，为这个新兴领域提供了有价值的见解，并为未来研究提供了灵感。
