Xu Liang, Jia Yuehui, Xiao Qiong
Department of State-Owned Assets Administration, Qiqihar Medical University, Qiqihar, Heilongjiang Province 161000 People's Republic of China.
Department of Epidemiology and Biostatistics, College of Public Health, Qiqihar Medical University, Qiqihar, Heilongjiang Province 161000 People's Republic of China.
Sleep Biol Rhythms. 2024 Jun 22;22(4):505-512. doi: 10.1007/s41105-024-00538-9. eCollection 2024 Oct.
The study aimed to discuss the association between sleep duration and the risk of hyperhomocysteinemia (Hhcy). This cross-sectional study included 4173 adults (≥ 20 years) from the National Health and Nutrition Examination Survey 2005-2006. According to their sleep duration, participants were divided into five subgroups. Multivariate logistic regression analysis models and restrictive cubic spline regressions were used to explore the association between sleep duration and the risk of Hhcy. Compared with the participants who sleep 7 h, sleep deprivation (≤ 5 h) increased the risk of Hhcy, odds ratio (OR) 1.68 (95% confidence interval (CI) 1.06-2.68); Excessive sleep (≥ 9 h) also increased the risk of Hhcy, OR 1.86 (95% CI 1.09-3.14) after adjusting for a series of confounding factors in the entire population. The risk of Hhcy was distributed in a U-shape with sleep duration. Similar results were demonstrated in obese populations. The association between sleep duration and the risk of Hhcy is U-shaped. Both sleep deprivation and excessive sleep can increase the risk of Hhcy.
该研究旨在探讨睡眠时间与高同型半胱氨酸血症（Hhcy）风险之间的关联。这项横断面研究纳入了来自2005 - 2006年美国国家健康与营养检查调查的4173名成年人（≥20岁）。根据睡眠时间，参与者被分为五个亚组。采用多因素逻辑回归分析模型和限制性立方样条回归来探讨睡眠时间与Hhcy风险之间的关联。与睡眠时间为7小时的参与者相比，睡眠不足（≤5小时）会增加Hhcy风险，比值比（OR）为1.68（95%置信区间（CI）为1.06 - 2.68）；在对整个人群的一系列混杂因素进行调整后，睡眠过多（≥9小时）也会增加Hhcy风险，OR为1.86（95%CI为1.09 - 3.14）。Hhcy风险随睡眠时间呈U形分布。在肥胖人群中也得到了类似的结果。睡眠时间与Hhcy风险之间的关联呈U形。睡眠不足和睡眠过多都会增加Hhcy风险。
