Sleep Medicine Centre, Department of Psychiatry, First Affiliated Hospital of Jinan University, Guangzhou, Guangdong Province, 510632, P.R. China.
J Health Popul Nutr. 2024 Aug 16;43(1):125. doi: 10.1186/s41043-024-00601-8.
Nowadays, few studies have examined the relationships between sleep duration and abnormal gut health. In this study, we used data from the National Health and Nutrition Examination Survey (NHANES) to investigate the correlations between habitual sleep duration and abnormal bowel symptoms in adults.
This study included 11,533 participants aged ≥ 20 years from the NHANES conducted during 2005-2010. Chronic constipation and chronic diarrhea were defined based on the Bristol Stool Form Scale (BSFS) and frequency of bowel movements. Sleep duration was assessed based on the self-report questionnaire and classified into three groups: short sleep duration (< 7 h), normal sleep duration (7-9 h), and long sleep duration (> 9 h). Weighted data were calculated according to analytical guidelines. Logistic regression models and restricted cubic spline curves (RCS) were used to assess and describe the association between sleep duration and chronic diarrhea and constipation. Univariate and stratified analyses were also performed.
There were 949 (7.27%) adults aged 20 years and older with chronic diarrhea and 1120 (8.94%) adults with constipation among the 11,533 individuals. A positive association was found between short sleep duration and chronic constipation, with a multivariate-adjusted OR of 1.32 (95% CI: 1.05-1.66). Additionally, long sleep duration was significantly associated with an increased risk of chronic diarrhea (OR: 1.75, 95% CI: 1.08-2.84, P = 0.026). The RCS models revealed a statistically significant nonlinear association (P for non-linearity < 0.05) between sleep duration and chronic diarrhea. Furthermore, obesity was found to modify the association between sleep duration and chronic diarrhea and constipation (p for interaction = 0.044).
This study suggests that both long and short sleep durations are associated with a higher risk of chronic diarrhea and constipation in the general population. Furthermore, a non-linear association between sleep duration and these conditions persists even after adjusting for case complexities.
目前，很少有研究探讨睡眠时长与肠道健康异常之间的关系。本研究利用美国国家健康和营养调查（NHANES）的数据，调查了成年人习惯性睡眠时长与肠道异常症状之间的相关性。
本研究纳入了 2005-2010 年 NHANES 中年龄≥20 岁的 11533 名参与者。慢性便秘和慢性腹泻分别根据布里斯托大便形状量表（BSFS）和排便频率来定义。睡眠时长根据自我报告问卷进行评估，并分为三组：短睡眠时长（<7 小时）、正常睡眠时长（7-9 小时）和长睡眠时长（>9 小时）。根据分析指南计算加权数据。采用逻辑回归模型和限制三次样条曲线（RCS）评估和描述睡眠时长与慢性腹泻和便秘之间的关系。还进行了单变量和分层分析。
在 11533 名参与者中，有 949 名（7.27%）20 岁及以上成年人患有慢性腹泻，1120 名（8.94%）成年人患有便秘。短睡眠时长与慢性便秘呈正相关，多变量校正后的比值比（OR）为 1.32（95%CI：1.05-1.66）。此外，长睡眠时长与慢性腹泻的风险增加显著相关（OR：1.75，95%CI：1.08-2.84，P=0.026）。RCS 模型显示睡眠时长与慢性腹泻之间存在统计学上显著的非线性关系（P<0.05）。此外，肥胖被发现可以改变睡眠时长与慢性腹泻和便秘之间的关联（交互作用 P=0.044）。
本研究表明，长睡眠和短睡眠时长均与普通人群中慢性腹泻和便秘的风险增加相关。此外，即使在调整了病例复杂性后，睡眠时长与这些疾病之间的关系仍然存在非线性。
