Huang K C, Sukegawa K, Orii T
Clin Chim Acta. 1985 Sep 30;151(2):141-6. doi: 10.1016/0009-8981(85)90317-1.
The measurement of glycosaminoglycans (GAGs) on a single random urine specimen in 405 healthy individuals and in 79 patients with mucopolysaccharidoses (MPSs) is described. The uronic acid (UA) content of the precipitated GAGs was estimated by the method of Bitter and Muir. The results were expressed as uronic acid to creatinine (UA/C) ratio. We found that the UA/C ratio decreased with age but had a rather constant low value between the ages of 20 and 33 in healthy individuals. Except for most patients with Morquio syndrome, the UA/C ratio in random urine samples was higher in patients with MPSs than in healthy individuals.
描述了对405名健康个体和79名黏多糖贮积症（MPS）患者单次随机尿液样本中糖胺聚糖（GAGs）的测量。通过Bitter和Muir方法估算沉淀的GAGs中糖醛酸（UA）含量。结果以糖醛酸与肌酐（UA/C）比值表示。我们发现，健康个体的UA/C比值随年龄下降，但在20至33岁之间具有相当恒定的低值。除了大多数Morquio综合征患者外，MPS患者随机尿液样本中的UA/C比值高于健康个体。
