慢性非甲非乙型病毒性肝炎中自身免疫血清学反应的缺失
Absence of autoimmune serological reactions in chronic non A, non B viral hepatitis.
作者信息
Mackay I R, Frazer I H, Toh B H, Pedersen J S, Alter H J
出版信息
Clin Exp Immunol. 1985 Jul;61(1):39-43.
In 18 cases of chronic liver disease due to non-A, non-B hepatitis virus(es) in which the diagnosis was established by transmission, including chimpanzee inoculation in nine, sera were tested for the autoantibodies characteristically associated with autoimmune chronic active hepatitis. The frequency of autoantibodies to nuclear, smooth muscle, cytofilament, mitochondrial and liver membrane antigens was low, being not greater than that recorded for a normal population, and the few positive reactions obtained were at very low titre. These findings suggest that among cases of 'HBsAg negative' chronic hepatitis, those due to NANB infection are distinguishable from those due to autoimmune chronic hepatitis by negative serological tests for autoantibodies.
在18例由非甲非乙型肝炎病毒引起的慢性肝病中，通过传播途径确诊，其中9例接种黑猩猩，检测血清中与自身免疫性慢性活动性肝炎相关的特征性自身抗体。针对核、平滑肌、细胞丝、线粒体和肝膜抗原的自身抗体频率较低，不高于正常人群记录的频率，且获得的少数阳性反应滴度非常低。这些发现表明，在“乙肝表面抗原阴性”的慢性肝炎病例中，由非甲非乙型感染引起的病例可通过自身抗体的血清学检测阴性与自身免疫性慢性肝炎引起的病例区分开来。
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