Van Acker Gustaf M, Vrabec Tina L, Bhadra Narendra, Chae John, Kilgore Kevin L, Bhadra Niloy
MetroHealth Rehabilitation Institute of Ohio, The MetroHealth System & Case Western Reserve University, Cleveland, OH 44109, USA.
Cleveland Functional Electrical Stimulation Center, Cleveland, OH 44106, USA.
Bioelectron Med (Lond). 2018;1(2):107-116. doi: 10.2217/bem-2017-0011. Epub 2018 May 25.
Nerve conduction block using implanted electrodes is being used increasingly for clinical applications. Alternatively, non-invasive electrical nerve block would be beneficial for applications including pain block and muscle spasticity. Here we developed a novel means of non-invasive electrical nerve conduction blockade - transcutaneous direct current block (tDCB) - that produces direct block of nerve conduction.
MATERIALS & METHODS: In an rodent model, tDCB produced stable neuromotor blockade of sciatic nerve branches, dependent on stimulus parameters and electrode geometry.
Partial-to-complete neuromotor block was achieved in all subjects using tDCB amplitudes at or below 20 mA, and complete block was achieved at amplitudes as low as 6 mA.
Our results reveal that neuromotor activity can be rapidly, reliably and reversibly blocked using tDCB.
使用植入电极进行神经传导阻滞在临床应用中越来越普遍。另外，非侵入性电神经阻滞对包括疼痛阻滞和肌肉痉挛在内的应用将是有益的。在此，我们开发了一种新型的非侵入性电神经传导阻滞方法——经皮直流电阻滞（tDCB）——它能直接阻断神经传导。
在啮齿动物模型中，tDCB可产生坐骨神经分支稳定的神经运动阻滞，这取决于刺激参数和电极几何形状。
所有受试者使用20 mA及以下的tDCB振幅均实现了部分至完全的神经运动阻滞，低至6 mA的振幅即可实现完全阻滞。
我们的结果表明，使用tDCB可快速、可靠且可逆地阻断神经运动活动。
