Vrabec T, Wainright J, Bhadra N, Bhadra N, Kilgore K
Dept of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Ave., Cleveland, Ohio 44106.
Dept of Chemical Engineering, Case Western Reserve University, 10900 Euclid Ave., Cleveland, Ohio 44106.
ECS Trans. 2013;50(28):31-37. doi: 10.1149/05028.0031ecst.
Functional Electrical Stimulation (FES) has widely been used to elicit neural activity to activate muscle for functional outcomes. But there are many diseases which result from undesirable neural activity which are equally debilitating. A localized, reversible, electrical nerve conduction block is an attractive way of addressing these conditions. High frequency alternating current (HFAC) has also been shown to generate a complete conduction block. But HFAC generates an "onset response" consisting of a short, but intense burst of firing at the start of the HFAC. This onset response can be eliminated by applying direct current (DC) briefly during onset duration. However, DC has been shown to cause nerve damage when applied for long durations. High surface area electrodes show promise in delivering DC without nerve damage.
功能性电刺激（FES）已被广泛用于引发神经活动，以激活肌肉从而实现功能结果。但有许多疾病是由不良神经活动导致的，这些疾病同样使人衰弱。局部、可逆的电神经传导阻滞是解决这些病症的一种有吸引力的方法。高频交流电（HFAC）也已被证明能产生完全传导阻滞。但HFAC会产生一种“起始反应”，即在HFAC开始时出现短暂但强烈的放电脉冲。在起始持续时间内短暂施加直流电（DC）可以消除这种起始反应。然而，已证明长时间施加DC会导致神经损伤。高表面积电极在输送DC而不造成神经损伤方面显示出前景。
