Han Boyue, Han Xiangchen, Luo Hong, Nasir Javaria, Chen Chao, Shao Zhiming, Ling Hong, Hu Xin
Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery Fudan University Shanghai Cancer Center Shanghai China.
Department of Oncology Shanghai Medical College, Fudan University Shanghai China.
Cancer Innov. 2024 Sep 19;3(5):e146. doi: 10.1002/cai2.146. eCollection 2024 Oct.
Triple-negative breast cancer (TNBC) displays high heterogeneity. The majority of TNBC cases are characterized by high Ki-67 expression. TNBC with low Ki-67 expression accounts for only a small fraction of cases and has been relatively less studied.
This study analyzed a large single-center multiomics TNBC data set, combined with a single-cell data set. The clinical, genomic, and metabolic characteristics of patients with low Ki-67 TNBC were analyzed.
The clinical and pathological characteristics were analyzed in 2217 TNBC patients. Low Ki-67 TNBC was associated with a higher patient age at diagnosis, a lower proportion of invasive ductal carcinoma, increased alterations in the PI3K-AKT-mTOR pathway, upregulated lipid metabolism pathways, and enhanced infiltration of M2 macrophages. High Ki-67 TNBC exhibited a higher prevalence of TP53 gene mutations, elevated nucleotide metabolism, and increased infiltration of M1 macrophages.
We identified specific genomic and metabolic characteristics unique to low Ki-67 TNBC, which have implications for the development of precision therapies and patient stratification strategies.
三阴性乳腺癌（TNBC）具有高度异质性。大多数TNBC病例的特征是Ki-67表达高。Ki-67表达低的TNBC病例仅占一小部分，且相关研究相对较少。
本研究分析了一个大型单中心多组学TNBC数据集，并结合了一个单细胞数据集。分析了Ki-67低表达TNBC患者的临床、基因组和代谢特征。
对2217例TNBC患者的临床和病理特征进行了分析。Ki-67低表达的TNBC与诊断时患者年龄较大、浸润性导管癌比例较低、PI3K-AKT-mTOR通路改变增加、脂质代谢途径上调以及M2巨噬细胞浸润增强有关。Ki-67高表达的TNBC表现出TP53基因突变的较高发生率、核苷酸代谢升高以及M1巨噬细胞浸润增加。
我们确定了Ki-67低表达TNBC特有的特定基因组和代谢特征，这对精准治疗的开发和患者分层策略具有重要意义。
