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本文引用的文献

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Emulsifiers are not necessary to make formulas for deep chemical peeling: Response to Wambier et al., "Advanced chemical peels: Phenol-croton oil peel".
J Am Acad Dermatol. 2024 Jun;90(6):e197-e198. doi: 10.1016/j.jaad.2023.12.067. Epub 2024 Feb 1.
2
Static glabellar lines can be treated using a superlocalized phenol-croton peel.静态眉间纹可通过超局部苯酚-巴豆油脱皮术进行治疗。
JAAD Int. 2022 Nov 23;11:63-64. doi: 10.1016/j.jdin.2022.11.007. eCollection 2023 Jun.
3
The effects of 35% trichloroacetic acid-Croton oil and 35% glycolic acid-Croton oil compared to 35% phenol-Croton oil Hetter's very heavy formula for deep chemical peel.与35%苯酚-巴豆油(Hetter超深度化学剥脱配方)相比,35%三氯乙酸-巴豆油和35%乙醇酸-巴豆油的效果。
J Am Acad Dermatol. 2022 Nov;87(5):1227-1229. doi: 10.1016/j.jaad.2022.07.023. Epub 2022 Jul 19.
4
Effect of Phenol Application Time in the Treatment of Onychocryptosis: A Randomized Double-Blind Clinical Trial.甲酚应用时间治疗甲下血管性嵌甲的效果:一项随机双盲临床试验。
Int J Environ Res Public Health. 2021 Oct 6;18(19):10478. doi: 10.3390/ijerph181910478.
5
Neocolagenesis by phenol-croton oil peel is independent from the MMP - 1/MMP-2/JunB and p53 pathways.
J Cosmet Dermatol. 2022 Apr;21(4):1766-1769. doi: 10.1111/jocd.14319. Epub 2021 Jul 24.
6
Medium-depth Trichloroacetic Acid and Deep Phenol-Croton Oil Chemical Peeling for Facial Rejuvenation: An Update.中深度三氯乙酸和深苯酚-巴豆油化学焕肤面部年轻化:更新。
J Craniofac Surg. 2021;32(8):e745-e750. doi: 10.1097/SCS.0000000000007729.
7
Commentary on Characterization of the Activity of Croton Tiglium Oil in Hetter's Very Heavy Phenol-Croton Oil Chemical Peels.
Dermatol Surg. 2021 Jul 1;47(7):947. doi: 10.1097/DSS.0000000000003131.
8
Phenol-croton oil peel enhances type-1 and type-3 collagen amounts by stimulating SIRT-6 and SIRT-7.
Int J Dermatol. 2022 Feb;61(2):e71-e74. doi: 10.1111/ijd.15720. Epub 2021 Jun 21.
9
Characterization of the Activity of Croton tiglium Oil in Hetter's Very Heavy Phenol-Croton Oil Chemical Peels. characterization of the activity of croton tiglium oil in hetter's very heavy phenol-croton oil chemical peels.
Dermatol Surg. 2021 Jul 1;47(7):944-946. doi: 10.1097/DSS.0000000000002990.
10
Depth of injury of Hetter's phenol-croton oil chemical peel formula using 2 different emulsifying agents.
J Am Acad Dermatol. 2020 Jun;82(6):1544-1546. doi: 10.1016/j.jaad.2020.02.064. Epub 2020 Mar 3.

苯酚/巴豆油的临床情况及风险

Clinical aspects and risks of the phenol/croton oil.

作者信息

Liapakis Ioannis E, Ismailos Georgios K, Michail Angelos, Tsakonis Georgios P, Gloustianou Georgia, Koliarakis Ioannis, Mandrekas Apostolos D

机构信息

Opsis Clinical Plastic and Reconstructive Surgery, 71304 Heraklion, Greece.

Experimental Research Center ELPEN, ELPEN Pharmaceuticals, 19009 Pikermi, Greece.

出版信息

Exp Ther Med. 2024 Sep 11;28(5):422. doi: 10.3892/etm.2024.12711. eCollection 2024 Nov.

DOI:10.3892/etm.2024.12711
PMID:39301260
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11412097/
Abstract

Phenol/croton oil is a unique chemical formulation promoting deep skin resurfacing and cellular renovation. Even though it has been used for decades in plastic surgery, the clinicopathological features, as well as the risks related to phenol/croton oil clinical application have not been thoroughly studied. The aim of the present study was to assess the effectiveness of the phenol/croton oil peel, the pathological characteristics from 1 patient at least and the emerging potential risks. A total of 64 patients were treated with phenol/croton oil peel between 2014 and 2023; in total, 21 of them underwent resurfacing at their oral area (upper/lower lips), 15 underwent resurfacing at their lower eyelid wrinkles, 22 patients underwent full face resurfacing, 2 patients were treated for their acne scars and additionally 4 patients were treated for multiple body seborrheic keratosis. The wrinkles, as well as the acne scars were markedly improved in all patients, the seborrheic keratosis was eliminated, while adverse events and undesired clinical manifestations related to peel intervention were mild and reversible for all patients. The application of phenol/croton oil constitutes an immensely powerful tool for deep chemical peeling and facial skin rejuvenation; nevertheless, it should be used cautiously due to its potential complications.

摘要

苯酚/巴豆油是一种促进深层皮肤表面更新和细胞修复的独特化学配方。尽管它在整形外科中已使用了数十年,但苯酚/巴豆油临床应用的临床病理特征以及相关风险尚未得到充分研究。本研究的目的是评估苯酚/巴豆油换肤术的有效性、至少1例患者的病理特征以及新出现的潜在风险。2014年至2023年期间,共有64例患者接受了苯酚/巴豆油换肤术;其中,21例患者的口腔区域(上/下唇)进行了表面更新,15例患者的下眼睑皱纹进行了表面更新,22例患者进行了全脸表面更新,2例患者接受了痤疮瘢痕治疗,另外4例患者接受了多处身体脂溢性角化病治疗。所有患者的皱纹以及痤疮瘢痕均有明显改善,脂溢性角化病得以消除,而与换肤干预相关的不良事件和不良临床表现对所有患者而言均较轻且可逆。苯酚/巴豆油的应用是深层化学换肤和面部皮肤年轻化的一种非常有效的工具;然而,由于其潜在并发症,应谨慎使用。