School of Chemistry and Environment, Jiaying University, Meizhou, China.
School of Physics and Electrical Engineering, Jiaying University, Meizhou, China.
Front Endocrinol (Lausanne). 2024 Sep 5;15:1459329. doi: 10.3389/fendo.2024.1459329. eCollection 2024.
Currently, although there have been a few reports on the endocrine-disrupting effects of neonicotinoids, the effect on Chironomidae during long-term exposure remains unknown.
Ecdysis and sex ratio, along with ecdysone-relevant gene expressions of representative neonicotinoid dinotefuran on were investigated at different environmental concentrations by long-term exposure.
A low dose of dinotefuran delayed pupation and emergence via inhibiting ecdysis. Sex ratios of adults shifted toward male-dominated populations with the concentration of dinotefuran increasing. The corresponding transcriptions of ecdysis genes , and were significantly downregulated in the midge. For estrogen effects, the gene expression was upregulated, but there was no significant change for the gene.
These results would improve our understanding of the endocrine-disrupting mechanisms of neonicotinoid insecticides to Chironomidae and provide data support for assessing their potential environmental risks.
目前，虽然已有一些关于新烟碱类杀虫剂内分泌干扰作用的报道，但长期暴露对摇蚊科的影响尚不清楚。
通过长期暴露，在不同环境浓度下研究了代表性新烟碱类杀虫剂噻虫嗪对 的蜕皮和性别比以及蜕皮相关基因表达的影响。
低剂量的噻虫嗪通过抑制蜕皮而延迟化蛹和羽化。随着噻虫嗪浓度的增加，成虫的性别比例向雄性主导种群倾斜。在摇蚊中，蜕皮基因 、 和 的相应转录物明显下调。对于雌激素作用， 基因表达上调，但 基因没有显著变化。
这些结果将提高我们对新烟碱类杀虫剂对摇蚊科内分泌干扰机制的认识，并为评估其潜在环境风险提供数据支持。
