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从精神病到康复：一例N-甲基-D-天冬氨酸（NMDA）受体脑炎病例报告

From Psychosis to Recovery: A Case Report of N-Methyl-D-Aspartate (NMDA) Receptor Encephalitis.

作者信息

Gopal Sava Nanda, Vakati Deepthi, Palanisamy Saranya, David Kanimozhi, Rajendran Kannan

机构信息

Internal Medicine, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.

出版信息

Cureus. 2024 Aug 20;16(8):e67272. doi: 10.7759/cureus.67272. eCollection 2024 Aug.

DOI:10.7759/cureus.67272
PMID:39301403
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11411395/
Abstract

Autoimmune N-methyl-D-aspartate (NMDA) receptor encephalitis is an increasingly recognized cause of severe neuropsychiatric illness, particularly in young individuals. This case report presents a detailed account of a patient diagnosed with NMDA receptor encephalitis, highlighting the clinical presentation, diagnostic challenges, and treatment approach. The patient exhibited initial symptoms of psychosis and memory disturbances, which rapidly progressed to seizures and autonomic instability, reflecting the characteristic progression of the disorder.

摘要

自身免疫性 N-甲基-D-天冬氨酸（NMDA）受体脑炎是一种日益被认识到的导致严重神经精神疾病的病因，尤其是在年轻人中。本病例报告详细描述了一名被诊断为 NMDA 受体脑炎的患者，突出了临床表现、诊断挑战和治疗方法。该患者最初表现出精神病和记忆障碍症状，迅速发展为癫痫发作和自主神经功能不稳定，反映了该疾病的典型病程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1569/11411395/a6a376c630f4/cureus-0016-00000067272-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1569/11411395/c4826f71cd21/cureus-0016-00000067272-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1569/11411395/627322c8c3db/cureus-0016-00000067272-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1569/11411395/4bac3eba0f89/cureus-0016-00000067272-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1569/11411395/a6a376c630f4/cureus-0016-00000067272-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1569/11411395/c4826f71cd21/cureus-0016-00000067272-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1569/11411395/627322c8c3db/cureus-0016-00000067272-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1569/11411395/4bac3eba0f89/cureus-0016-00000067272-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1569/11411395/a6a376c630f4/cureus-0016-00000067272-i04.jpg

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本文引用的文献

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Therapeutic potential of N-methyl-D-aspartate receptor modulators in psychiatry.N-甲基-D-天冬氨酸受体调节剂在精神病学中的治疗潜力。
Neuropsychopharmacology. 2024 Jan;49(1):51-66. doi: 10.1038/s41386-023-01614-3. Epub 2023 Jun 27.
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Anti-NMDA Receptor Autoimmune Encephalitis: Diagnosis and Management Strategies.抗N-甲基-D-天冬氨酸受体自身免疫性脑炎：诊断与管理策略
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A case report: anti-NMDA receptor encephalitis.病例报告：抗N-甲基-D-天冬氨酸受体脑炎
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Anti-N-methyl-d-aspartate receptor encephalitis: review of clinical presentation, diagnosis and treatment.抗N-甲基-D-天冬氨酸受体脑炎：临床表现、诊断及治疗综述
BJPsych Bull. 2015 Feb;39(1):19-23. doi: 10.1192/pb.bp.113.045518.
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Herpes simplex virus encephalitis is a trigger of brain autoimmunity.单纯疱疹病毒性脑炎是脑自身免疫的触发因素。
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Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study.抗 NMDA 受体脑炎患者的长期预后的治疗和预后因素：一项观察性队列研究。
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