Department of Nephrology, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China.
Sichuan Clinical Research Center for Nephrology, Luzhou, Sichuan, China.
Clin Toxicol (Phila). 2024 Nov;62(11):707-713. doi: 10.1080/15563650.2024.2402501. Epub 2024 Sep 20.
Amatoxin-containing mushroom poisoning is a significant threat to public health worldwide. We report a mass poisoning of -like mushrooms (Galerina cf. sulciceps) in Luzhou, Sichuan Province, China, aiming to offer insights for future prevention and treatment strategies.
We performed a retrospective survey of mass mushroom poisoning patients admitted to our hospital. The demographic data, clinical presentations, laboratory findings, therapeutic measures and prognostic information were collected and analyzed. We used the 2020 Chinese consensus on the clinical diagnosis and treatment of amatoxin-containing mushroom poisoning to assess the severity of poisoning. Mushrooms were examined through morphological analysis, molecular biology identification, and toxin detection.
Our patient cohort consisted of nine males and six females, with mean (±SD) age of 34.9 ± 13.0 years. Gastrointestinal symptoms were the first to manifest, with mean (±SD) latency period of 13.4 ± 3.9 h. The majority of patients (86.7%) experienced nausea, vomiting, and diarrhea. Liver dysfunction was noted in 66.7% of patients, and thrombocytopenia was present in 26.7% of patients. In terms of the severity of poisoning, there were 10 mild cases and five severe cases. The mushrooms were provisionally labeled as , containing the toxins α-amanitin, β-amanitin, and γ-amanitin. All patients eventually recovered.
We report what appears to be a new type of mushroom that is morphologically and phylogenetically similar to the known , but further study is required to determine if it represents a distinct species.
This poisoning event was caused by unintentional ingestion of , an amatoxin-containing mushroom. Early symptoms are primarily gastrointestinal, with acute liver damage and coagulopathy being the main toxic effects. Thrombocytopenia is also prominent, particularly in severe cases. Accurate assessment and prompt, individualized, and intensive treatment are crucial for managing patients with acute poisoning effectively.
含鹅膏肽类蘑菇中毒对全球公共健康构成重大威胁。本研究报告了一起在中国四川省泸州市发生的毒蝇伞（Galerina cf. sulciceps）蘑菇中毒事件，旨在为今后的预防和治疗策略提供参考。
我们对我院收治的蘑菇中毒患者进行了回顾性调查。收集并分析了患者的人口统计学数据、临床表现、实验室检查结果、治疗措施和预后信息。采用 2020 年中国鹅膏肽类蘑菇中毒临床诊断和治疗共识评估中毒严重程度。通过形态学分析、分子生物学鉴定和毒素检测对蘑菇进行了检测。
患者组由 9 名男性和 6 名女性组成，平均（±标准差）年龄为 34.9±13.0 岁。首发症状为胃肠道症状，潜伏期平均（±标准差）为 13.4±3.9 小时。大多数患者（86.7%）出现恶心、呕吐和腹泻。66.7%的患者出现肝功能异常，26.7%的患者出现血小板减少。根据中毒严重程度，有 10 例轻度中毒和 5 例重度中毒。蘑菇暂被标记为 ，含有α-鹅膏肽、β-鹅膏肽和γ-鹅膏肽。所有患者最终均康复。
我们报告了一种新的蘑菇类型，它在形态学和系统发育上与已知的相似，但需要进一步研究来确定它是否代表一个独特的物种。
此次中毒事件是由误食 引起的， 是一种含鹅膏肽类蘑菇。早期症状主要为胃肠道，急性肝损伤和凝血功能障碍是主要的毒性作用。血小板减少也很明显，尤其是在重度中毒患者中。准确评估并及时、个体化、强化治疗对于有效管理急性 中毒患者至关重要。
