Yin W, Yang Z R
ICU Fourth Hospital of Chongqing.
Zhonghua Nei Ke Za Zhi. 1993 Dec;32(12):810-2.
Twelve patients with Galerina Autumnalis (GA) poisoning were treated. Amatoxin and phallotoxin are the principal toxins of GA. After absorption from intestine into the liver, the toxins combine with RNA polymerase, resulting in block of messenger (mRNA) synthesis, hepatocellular damage, hepatitis, hepatic necrosis, serious coagulation abnormalities and DIC. The clinical characteristics are long latent period, short period of "pseudo-remission" and serious liver dysfunction. These were pathologically confirmed by autopsy. Our experiences with this poisoning are as follows: treatment should be carried out as early as possible, especially with gastric lavage and catharsis and special attention paid to the "pseudo-remission".
对12例秋生盔孢伞中毒患者进行了治疗。鹅膏毒肽和鬼笔毒肽是秋生盔孢伞的主要毒素。毒素从肠道吸收进入肝脏后，与RNA聚合酶结合，导致信使核糖核酸（mRNA）合成受阻、肝细胞损伤、肝炎、肝坏死、严重凝血异常和弥散性血管内凝血（DIC）。临床特征为潜伏期长、“假缓解期”短和严重肝功能障碍。这些经尸检病理证实。我们对这种中毒的经验如下：应尽早进行治疗，尤其是洗胃和导泻，并特别注意“假缓解期”。
