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生活史策略和栖息地对无肺螈科蝾螈肢体再生的影响。

Effects of life history strategies and habitats on limb regeneration in plethodontid salamanders.

作者信息

Bothe Vivien, Müller Hendrik, Shubin Neil, Fröbisch Nadia

机构信息

Museum für Naturkunde Berlin, Leibniz Institute for Evolution and Biodiversity Science, Berlin, Germany.

Department of Biology, Humboldt University Berlin, Berlin, Germany.

出版信息

Dev Dyn. 2025 May;254(5):396-419. doi: 10.1002/dvdy.742. Epub 2024 Sep 20.

DOI:10.1002/dvdy.742
PMID:39301774
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12047434/
Abstract

BACKGROUND

Salamanders are the only tetrapods that exhibit the ability to fully regenerate limbs. The axolotl, a neotenic salamander, has become the model organism for regeneration research. Great advances have been made providing a detailed understanding of the morphological and molecular processes involved in limb regeneration. However, it remains largely unknown how limb regeneration varies across salamanders and how factors like variable life histories, ecologies, and limb functions have influenced and shaped regenerative capacities throughout evolution.

RESULTS

This study focuses on six species of plethodontid salamanders representing distinct life histories and habitats. Specimens were examined for regeneration ability after bite injuries as well as after controlled amputations. Morphological investigations revealed great regenerative abilities in all investigated species and frequent anatomical limb anomalies. Correlations were observed with respect to speed of regeneration and habitat.

CONCLUSIONS

Investigating regeneration in non-model salamander taxa is essential for disentangling shared features of the regeneration process versus those that may be more taxon-specific. Gaining insights into variable aspects of regeneration under natural conditions and after conspecific biting rather than controlled amputations adds important new datapoints for understanding the evolutionary framework of regeneration and provides a broader context for interpreting findings made in the model organism axolotl.

摘要

背景

蝾螈是唯一具有四肢完全再生能力的四足动物。美西钝口螈，一种幼态持续的蝾螈，已成为再生研究的模式生物。在详细了解肢体再生所涉及的形态学和分子过程方面已经取得了巨大进展。然而，在整个蝾螈群体中肢体再生如何变化，以及诸如不同的生活史、生态和肢体功能等因素在进化过程中如何影响和塑造再生能力，在很大程度上仍然未知。

结果

本研究聚焦于六种代表不同生活史和栖息地的无肺螈科蝾螈。对标本在咬伤以及可控截肢后进行再生能力检查。形态学研究揭示了所有被研究物种都具有很强的再生能力以及频繁出现的解剖学肢体异常。观察到再生速度与栖息地之间存在相关性。

结论

研究非模式蝾螈类群的再生对于区分再生过程的共同特征与可能更具分类群特异性的特征至关重要。了解自然条件下以及同种咬伤而非可控截肢后的再生可变方面，为理解再生的进化框架增添了重要的新数据点，并为解释模式生物美西钝口螈的研究结果提供了更广泛的背景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/223c/12047434/ca9b612a84f6/DVDY-254-396-g012.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/223c/12047434/b6261c12f2ab/DVDY-254-396-g016.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/223c/12047434/1ab842778977/DVDY-254-396-g011.jpg
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