不同年龄无痛胃镜检查患者酒石酸布托啡诺的有效剂量。
The effective dose of butorphanol tartrate in patients of different ages undergoing painless gastroscopy.
机构信息
Department of Anesthesiology, Binzhou Medical University Hospital, No. 661 Huanghe 2nd Road, Binzhou, Shandong, China.
出版信息
J Int Med Res. 2024 Sep;52(9):3000605241277689. doi: 10.1177/03000605241277689.
OBJECTIVE
This study evaluated the 50% effective dose (ED) and 95% effective dose (ED) of butorphanol tartrate in patients undergoing painless gastroscopy.
METHODS
Patients who underwent painless gastroscopy at Binzhou Medical University Hospital were divided into the youth, middle-aged, and older groups. The ED and ED required for successful sedation using butorphanol tartrate were measured using the Dixon up-and-down method in patients in the different age groups. Patients in each group were administered intravenous butorphanol 5 minutes before gastroscopy. Each patient was administered 2 mg/kg propofol. The ED and ED of butorphanol were calculated using probit analysis.
RESULTS
In total, 95 patients were included. The EDs of butorphanol in the youth, middle-aged, and older groups were 7.384, 6.657, and 6.364 μg/kg, respectively. The EDs of butorphanol doses in these groups were 9.108, 8.419, and 7.348 μg/kg, respectively.
CONCLUSIONS
The ED and ED varied among the age groups, indicating that the effective dose decreases with age.
目的
本研究评估了酒石酸布托啡诺在无痛胃镜检查患者中的半数有效剂量（ED）和 95%有效剂量（ED）。
方法
将滨州医学院附属医院行无痛胃镜检查的患者分为青年组、中年组和老年组。采用 Dixon 上下法测量不同年龄组患者使用酒石酸布托啡诺成功镇静所需的 ED 和 ED。在胃镜检查前 5 分钟，每组患者静脉注射布托啡诺 2mg/kg。使用概率分析计算布托啡诺的 ED 和 ED。
结果
共纳入 95 例患者。青年组、中年组和老年组酒石酸布托啡诺的 ED 分别为 7.384、6.657 和 6.364μg/kg，ED 分别为 9.108、8.419 和 7.348μg/kg。
结论
各年龄组的 ED 和 ED 不同，表明有效剂量随年龄增长而降低。
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